Effect of phenytoin on plasma clozapine concentrations in two patients

D D Miller

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Effect of phenytoin on plasma clozapine concentrations in two patients

Journal article

Peer reviewed

Effect of phenytoin on plasma clozapine concentrations in two patients

D D Miller

The journal of clinical psychiatry, Vol.52(1), pp.23-25

01/1991

PMID: 1988414

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Abstract

Little is known about interactions of other drugs with the recently marketed antipsychotic clozapine. Two cases in which the addition of phenytoin caused a decrease in plasma clozapine concentrations and worsening of psychoses are described, and possible explanations are discussed.

Clozapine - therapeutic use

Humans

Psychotic Disorders - psychology

Male

Psychotic Disorders - blood

Drug Interactions

Phenytoin - therapeutic use

Phenytoin - adverse effects

Adult

Female

Phenytoin - pharmacology

Clozapine - blood

Psychotic Disorders - drug therapy

Clozapine - adverse effects

Drug Therapy, Combination

Details

Title: Subtitle: Effect of phenytoin on plasma clozapine concentrations in two patients
Creators: D D Miller - Department of Psychiatry, College of Medicine, University of Iowa, Iowa City 52242
Resource Type: Journal article
Publication Details: The journal of clinical psychiatry, Vol.52(1), pp.23-25
Publisher: United States
PMID: 1988414
ISSN: 0160-6689
eISSN: 1555-2101
Grant note: 5 P50 MH43271 / NIMH NIH HHS
Language: English
Date published: 01/1991
Academic Unit: Psychiatry
Record Identifier: 9984003407102771

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