Journal article
Effect of poloxamer 407 gel on the miotic activity of pilocarpine nitrate in rabbits
International journal of pharmaceutics, Vol.12(2), pp.147-152
1982
DOI: 10.1016/0378-5173(82)90114-4
Abstract
This study was designed to evaluate poloxamer 407 gel, relative to its suitability for use as a vehicle for ophthalmic drug delivery. Pilocarpine nitrate was incorporated into 25% poloxamer gel and the formulation was administered topically to rabbit eyes. The ocular activity of pilocarpine was assessed using the pharmacological response of miosis. The change in pupillary diameter versus time curve was compared to that obtained with an aqueous pilocarpine solution, dosed under similar conditions. As indicated by the miotic response, the gel formulation appeared to enhance the activity of pilocarpine when compared to the aqueous solution.
Details
- Title: Subtitle
- Effect of poloxamer 407 gel on the miotic activity of pilocarpine nitrate in rabbits
- Creators
- Susan C. Miller - University of MinnesotaMaureen D. Donovan - University of Minnesota
- Resource Type
- Journal article
- Publication Details
- International journal of pharmaceutics, Vol.12(2), pp.147-152
- Publisher
- Elsevier B.V
- DOI
- 10.1016/0378-5173(82)90114-4
- ISSN
- 0378-5173
- eISSN
- 1873-3476
- Language
- English
- Date published
- 1982
- Academic Unit
- Pharmaceutical Sciences and Experimental Therapeutics
- Record Identifier
- 9984365879102771
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