Journal article
Effect of polybrominated diphenyl ether congeners on placental cytokine production
Journal of reproductive immunology, Vol.125, pp.72-79
02/2018
DOI: 10.1016/j.jri.2017.12.002
PMID: 29306095
Abstract
Polybrominated diphenyl ethers (PBDEs) are pollutants that may increase the risk of preterm birth. In previous studies, we found that a mixture of PBDEs altered the expression of biomarkers for preterm birth by the placenta. However, there are 209 different PBDE congeners with different tissue distributions. How these different congeners may alter the production of immunomodulators by the placenta that help to maintain the survival of the fetal allograft is unclear. Therefore, we compared the effects 5 common congeners on basal and bacteria-stimulated cytokine production by the placenta. Placental explant cultures were incubated with 20 μM of PBDE congeners 47, 99, 100, 153, 209 or vehicle in the presence and absence of Escherichia coli for 20 h. Conditioned medium was harvested and concentrations of IL-1β, TNF-α, IL-6, sgp130, HO-1, IL-10, BDNF, and 8-IsoP quantified. For unstimulated cultures, all congeners, except for PBDE-47, reduced the production of IL-1β and IL-6 production was enhanced by PBDE-153. BDNF concentrations tended to be reduced by most PBDE congeners and IL-10 production was enhanced by PBDE-99, -153, and -209. 8-IsoP production was enhanced by PBDE-153, but not the other congeners. For bacteria-stimulated cultures, PBDE-47 increased IL-1β production and PBDE-47, -153, and -209 tended to reduce TNF-α production. IL-6 production was enhanced by all PBDEs except 153. IL-10 production was enhanced by all congeners except for PBDE-47. All congeners significantly enhanced BDNF and 8-IsoP. These results suggest that PBDEs can alter the expression of placental biomarkers in a congener and infection-dependent manner.
Details
- Title: Subtitle
- Effect of polybrominated diphenyl ether congeners on placental cytokine production
- Creators
- Yuko Arita - Department of Biomedical Research, NYU-Winthrop, Mineola, NY, United StatesCorinne Yeh - Department of Obstetrics and Gynecology, Winthrop University Hospital, Mineola, NY, United States; Department of Obstetrics and Gynecology and Women's Health, Jacobi Medical Center, Bronx, NY, United StatesTheodosia Thoma - Department of Biomedical Research, NYU-Winthrop, Mineola, NY, United StatesDarios Getahun - Department of Research and Evaluation, Kaiser-Permenante Southern California, Pasadena, CA, United StatesRamkumar Menon - Department of Obstetrics and Gynecology, UTMB-Galveston, Galveston, TX, United StatesMorgan R Peltier - Department of Biomedical Research, NYU-Winthrop, Mineola, NY, United States; Department of Obstetrics and Gynecology, Winthrop University Hospital, Mineola, NY, United States. Electronic address: mpeltier@winthrop.org
- Resource Type
- Journal article
- Publication Details
- Journal of reproductive immunology, Vol.125, pp.72-79
- DOI
- 10.1016/j.jri.2017.12.002
- PMID
- 29306095
- ISSN
- 0165-0378
- eISSN
- 1872-7603
- Grant note
- R01 ES023116 / National Institute of Environmental Health Sciences
- Language
- English
- Date published
- 02/2018
- Academic Unit
- Pulmonary Medicine; Stead Family Department of Pediatrics
- Record Identifier
- 9984093228902771
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