Journal article
Effect of prophylaxis on fungal infection and costs for high-risk liver transplant recipients
Liver transplantation, Vol.13(12), pp.1743-1750
12/01/2007
DOI: 10.1002/lt.21331
PMID: 18044769
Abstract
We sought to determine whether the prophylactic use of amphotericin B products (conventional amphotericin B and liposomal amphotericin B) reduces the incidence of fungal infections in high-risk liver transplant recipients, and if so, whether this lowers the cost of care. The study sample comprised 232 adult orthotopic liver transplants performed from 1994 to 2005 at a single center for patients classified as being at high risk for fungal infections. High-risk patients who received transplants with a prophylaxis regimen of amphotericin B (n = 58 transplants) were compared with high-risk patients who received no prophylaxis (n = 174 transplants). Fungal infections occurred in 3 transplants (5.17%) of those who received amphotericin B and 28 transplants (16.09%) in those without prophylaxis (P = 0.0432). Regression models were used to analyze fungal infection and costs for the 232 high-risk transplants. Failure to offer prophylaxis conferred a 4-fold greater risk of fungal infection (P = 0.046) compared with those who received amphotericin B. A fungal infection in a high-risk recipient increased mean costs by 46.48%. The indirect effect of prophylaxis (operating through infection reduction) is estimated to reduce overall costs in high-risk patients by 8.73%.
Details
- Title: Subtitle
- Effect of prophylaxis on fungal infection and costs for high-risk liver transplant recipients
- Creators
- Alan Reed - University of FloridaJill Boylston HerndonNail Ersoz - University of FloridaTakahisa Fujikawa - University of FloridaDenise Schain - Florida CollegePaul Lipori - UF Health Shands HospitalAlan Hemming - University of FloridaQin Li - University of FloridaElizabeth Shenkman - University of FloridaBruce Vogel - University of Florida
- Resource Type
- Journal article
- Publication Details
- Liver transplantation, Vol.13(12), pp.1743-1750
- DOI
- 10.1002/lt.21331
- PMID
- 18044769
- NLM abbreviation
- Liver Transpl
- ISSN
- 1527-6465
- eISSN
- 1527-6473
- Publisher
- Wiley
- Number of pages
- 8
- Language
- English
- Date published
- 12/01/2007
- Academic Unit
- Accounting; Surgery; Public Policy Center (Archive)
- Record Identifier
- 9984283561802771
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