Journal article
Effect of quadriceps strength and proprioception on risk for knee osteoarthritis
Medicine and science in sports and exercise, Vol.42(11), pp.2081-2088
11/2010
DOI: 10.1249/MSS.0b013e3181dd902e
PMCID: PMC2921020
PMID: 20351594
Abstract
Impaired quadriceps strength and joint position sense (JPS) have been linked with knee osteoarthritis (OA) cross-sectionally. Although neither has been independently associated with incident radiographic OA, their combination may mediate risk. The purpose of this study was to determine whether better sensorimotor function protects against the development of incident radiographic or symptomatic knee OA.
The Multicenter Osteoarthritis study is a longitudinal study of adults aged 50–79 yr at high risk for knee OA. Participants underwent bilateral, weight-bearing, fixed-flexion radiographs, JPS acuity tests, and isokinetic quadriceps strength tests. The relationships between combinations of the tertiles of sex-specific baseline peak strength and mean JPS and development of incident radiographic (Kellgren–Lawrence (KL) grade Q2) or symptomatic knee OA (KL grade Q2 and frequent knee pain or stiffness) at a 30-month follow-up were evaluated. Secondary analyses defined JPS as the variance during the 10 JPS trials and also assessed the interaction of strength and JPS in predicting each outcome.
The study of incident radiographic knee OA included 1390 participants (age = 61.2 ± 7 .9 yr and body mass index = 29.4 ± 5.1 kg·m−²), and the study of incident symptomatic knee OA included 1829 participants (age = 62.2 ± 8.0 yr and body mass index = 30.0 ± 5.4 kg·m−²). Greater strength at baseline protected against incident symptomatic but not radiographic knee OA regardless of JPS tertile. There was no significant relationship between the strength–JPS interaction and the development of radiographic or symptomatic knee OA.
The finding that quadriceps strength protected against incident symptomatic but not radiographic knee OA regardless of JPS tertile suggests that strength may be more important than JPS in mediating risk for knee OA.
Details
- Title: Subtitle
- Effect of quadriceps strength and proprioception on risk for knee osteoarthritis
- Creators
- Neil A Segal - Departments of Orthopaedics and Rehabilitation, Radiology, and Epidemiology, The University of Iowa, Iowa City, IA 52242-1088, USA. segal-research@uiowa.eduNatalie A GlassDavid T FelsonMichael HurleyMei Yang - Boston UniversityMichael NevittCora E LewisJames C Torner
- Resource Type
- Journal article
- Publication Details
- Medicine and science in sports and exercise, Vol.42(11), pp.2081-2088
- DOI
- 10.1249/MSS.0b013e3181dd902e
- PMID
- 20351594
- PMCID
- PMC2921020
- NLM abbreviation
- Med Sci Sports Exerc
- ISSN
- 0195-9131
- eISSN
- 1530-0315
- Publisher
- United States
- Grant note
- U01 AG018947 / NIA NIH HHS U01 AG018832 / NIA NIH HHS U01 AG019069 / NIA NIH HHS AG19069 / NIA NIH HHS AG18947 / NIA NIH HHS AG18832 / NIA NIH HHS K23 AG030945 / NIA NIH HHS AG18820 / NIA NIH HHS K23AG030945 / NIA NIH HHS U01 AG018820 / NIA NIH HHS
- Language
- English
- Date published
- 11/2010
- Academic Unit
- Epidemiology; Orthopedics and Rehabilitation; Surgery; Injury Prevention Research Center; Neurosurgery
- Record Identifier
- 9983995150502771
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