Effect of removal of the endothelium on vasocontraction in canine and rabbit basilar arteries

Tadayoshi Nakagomi; Neal F Kassell; Tomio Sasaki; R Michael Lehman; James C Torner; Kazuhiro Hongo; Joung H Lee

doi:10.3171/jns.1988.68.5.0757

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Effect of removal of the endothelium on vasocontraction in canine and rabbit basilar arteries

Journal article

Peer reviewed

Effect of removal of the endothelium on vasocontraction in canine and rabbit basilar arteries

Tadayoshi Nakagomi, Neal F Kassell, Tomio Sasaki, R Michael Lehman, James C Torner, Kazuhiro Hongo and Joung H Lee

Journal of neurosurgery, Vol.68(5), pp.757-766

05/1988

DOI: 10.3171/jns.1988.68.5.0757

PMID: 2895803

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Abstract

The effect of endothelium removal on the contractile responses to KCl, hemoglobin, serotonin (5-HT), norepinephrine (NE), prostaglandin (PG)F2 alpha, PGD2, and PGE2 was investigated in canine and rabbit basilar arteries by an isometric tension-recording method. In canine basilar arteries, endothelium removal elevated the dose-response curves to 5-HT, PGF2 alpha, and PGD2, and PGE2, but not to KCl, hemoglobin, or NE. In rabbit basilar arteries, on the other hand, removal of the endothelium elevated the dose-response curves to 5-HT, NE, PGF2 alpha, and PGD2, but not to KCl or hemoglobin. Neither contractile nor inhibitory response was elicited by PGE2 in rabbit basilar arteries. Contraction induced by 5-HT and NE following endothelium removal had a much more pronounced effect in rabbit basilar arteries than in canine basilar arteries. These results suggest that, following endothelium removal, abolition of the spontaneous release of endothelium-derived relaxing factor is the most probable mechanism of the enhanced vasocontraction. Since endothelial damage results from subarachnoid hemorrhage, the aforementioned mechanism of vasocontraction enhancement may play a role in the pathogenesis of cerebral vasospasm.

Norepinephrine - pharmacology

Species Specificity

Prostaglandins - pharmacology

Biological Products - secretion

Prostaglandins E - pharmacology

Dinoprostone

Male

Serotonin - pharmacology

Dose-Response Relationship, Drug

Dogs - physiology

Neurotransmitter Agents - pharmacology

Potassium Chloride - pharmacology

Prostaglandins F - pharmacology

Female

Rabbits - physiology

Basilar Artery - physiology

Hemoglobins - pharmacology

Basilar Artery - drug effects

Dinoprost

Vasodilator Agents - secretion

Nitric Oxide

Prostaglandin D2

Vasoconstriction - drug effects

Animals

Prostaglandins D - pharmacology

Endothelium - physiology

Details

Title: Subtitle: Effect of removal of the endothelium on vasocontraction in canine and rabbit basilar arteries
Creators: Tadayoshi Nakagomi - Department of Neurological Surgery, University of Virginia School of Medicine, Charlottesville
Neal F Kassell
Tomio Sasaki
R Michael Lehman
James C Torner
Kazuhiro Hongo
Joung H Lee - University of Virginia Medical Center
Resource Type: Journal article
Publication Details: Journal of neurosurgery, Vol.68(5), pp.757-766
DOI: 10.3171/jns.1988.68.5.0757
PMID: 2895803
NLM abbreviation: J Neurosurg
ISSN: 0022-3085
eISSN: 1933-0693
Publisher: United States
Language: English
Date published: 05/1988
Academic Unit: Epidemiology; Surgery; Injury Prevention Research Center; Neurosurgery
Record Identifier: 9983995149402771

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