Effect of renal denervation on urine angiotensinogen excretion in prenatally programmed rats

Asifhusen Mansuri; Susan K Legan; Jyoti Jain; Issa Alhamoud; Jyothsna Gattineni; Michel Baum

doi:10.14814/phy2.13482

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Effect of renal denervation on urine angiotensinogen excretion in prenatally programmed rats

Journal article

Open access

Peer reviewed

Effect of renal denervation on urine angiotensinogen excretion in prenatally programmed rats

Asifhusen Mansuri, Susan K Legan, Jyoti Jain, Issa Alhamoud, Jyothsna Gattineni and Michel Baum

Physiological reports, Vol.5(20), pp.e13482-n/a

11/2017

DOI: 10.14814/phy2.13482

PMCID: PMC5661239

PMID: 29051307

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Abstract

Prenatal programming results in an increase in blood pressure in adult offspring. We have shown that compared to control adult offspring whose mothers were fed a 20% protein diet, programmed adults whose mothers were fed a 6% protein diet during the last half of pregnancy have an increase in renal sympathetic nerve activity and urinary angiotensinogen/creatinine levels. We hypothesized that the increase in urinary angiotensinogen was mediated by renal sympathetic nerve activity in programmed rats. In this study performed in 3 month old rats, renal denervation resulted in normalization of blood pressure in the 6% programmed group (150 ± 3 Hg in 6% sham vs. 121 ± 4 Hg in 6% denervated, < 0.001), and a reduction in blood pressure in the 20% group (126 ± 2 Hg 20% sham vs. 113 ± 4 Hg 20% denervated ( < 0.05). We confirm that the intrarenal renin-angiotensin system assessed by urinary angiotensinogen/creatinine is upregulated in offspring of rats fed a 6% protein diet rats compared to 20% controls. To determine if sympathetic nerve activity was mediating the increase in urinary angiotensinogen in programmed rats, we compared denervated to sham-operated control and programmed rats. Renal denervation had no effect on urinary angiotensinogen/creatinine ratio in the 20% group and no effect on the increased urinary angiotensinogen/creatinine ratio found in programmed rats. This study demonstrates that the increase in urinary angiotensinogen in programmed rats is not mediated by renal sympathetic nerve activity.

Angiotensinogen - urine

Animals

Blood Pressure

Caloric Restriction - adverse effects

Creatinine - urine

Denervation

Female

Fetal Growth Retardation - etiology

Fetal Growth Retardation - physiopathology

Hypertension - etiology

Hypertension - physiopathology

Kidney - innervation

Kidney - physiology

Kidney - physiopathology

Male

Rats

Rats, Sprague-Dawley

Renin-Angiotensin System

Sympathetic Nervous System - physiology

Sympathetic Nervous System - physiopathology

Details

Title: Subtitle: Effect of renal denervation on urine angiotensinogen excretion in prenatally programmed rats
Creators: Asifhusen Mansuri - The University of Texas Southwestern Medical Center
Susan K Legan - The University of Texas Southwestern Medical Center
Jyoti Jain - The University of Texas Southwestern Medical Center
Issa Alhamoud - The University of Texas Southwestern Medical Center
Jyothsna Gattineni - The University of Texas Southwestern Medical Center
Michel Baum - The University of Texas Southwestern Medical Center
Resource Type: Journal article
Publication Details: Physiological reports, Vol.5(20), pp.e13482-n/a
DOI: 10.14814/phy2.13482
PMID: 29051307
PMCID: PMC5661239
NLM abbreviation: Physiol Rep
ISSN: 2051-817X
eISSN: 2051-817X
Grant note: DOI: 10.13039/100000002, name: National Institutes of Health, award: DK078596, 1P30DK079328-01
Language: English
Date published: 11/2017
Academic Unit: Stead Family Department of Pediatrics
Record Identifier: 9984353830902771

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