Journal article
Effect of selection bias on two sample summary data based Mendelian randomization
Scientific reports, Vol.11(Apr (E-published)), pp.7585-7585
01/01/2021
DOI: 10.1038/s41598-021-87219-6
PMCID: PMC8027662
PMID: 33828182
Abstract
Mendelian randomization (MR) is becoming more and more popular for inferring causal relationship between an exposure and a trait. Typically, instrument SNPs are selected from an exposure GWAS based on their summary statistics and the same summary statistics on the selected SNPs are used for subsequent analyses. However, this practice suffers from selection bias and can invalidate MR methods, as showcased via two popular methods: the summary data-based MR (SMR) method and the two-sample MR Steiger method. The SMR method is conservative while the MR Steiger method can be either conservative or liberal. A simple and yet more powerful alternative to SMR is proposed.
Details
- Title: Subtitle
- Effect of selection bias on two sample summary data based Mendelian randomization
- Creators
- Kai Wang - Iowa City, 52242 USAShizhong Han - Baltimore, 21205 USA Baltimore, 21205 USA
- Resource Type
- Journal article
- Publication Details
- Scientific reports, Vol.11(Apr (E-published)), pp.7585-7585
- DOI
- 10.1038/s41598-021-87219-6
- PMID
- 33828182
- PMCID
- PMC8027662
- NLM abbreviation
- Sci Rep
- ISSN
- 2045-2322
- eISSN
- 2045-2322
- Publisher
- Nature Publishing Group UK
- Language
- English
- Date published
- 01/01/2021
- Academic Unit
- Psychiatry; Biostatistics
- Record Identifier
- 9984214710102771
Metrics
8 Record Views