Effect of sex on glomerular filtration rate in programmed rats by prenatal dexamethasone

Jyoti Jain; Susan K Legan; Issa Alhamoud; Jyothsna Gattineni; Michel Baum

doi:10.14814/phy2.14154

Back

Effect of sex on glomerular filtration rate in programmed rats by prenatal dexamethasone

Journal article

Open access

Peer reviewed

Effect of sex on glomerular filtration rate in programmed rats by prenatal dexamethasone

Jyoti Jain, Susan K Legan, Issa Alhamoud, Jyothsna Gattineni and Michel Baum

Physiological reports, Vol.7(12), pp.e14154-n/a

07/2019

DOI: 10.14814/phy2.14154

PMCID: PMC6594923

PMID: 31243892

Files and links (1)

url

https://doi.org/10.14814/phy2.14154View

Published (Version of record) Open Access

Abstract

We have previously demonstrated that dexamethasone administered to pregnant rats during specific times during gestation results in a reduction in glomerular number and hypertension in offspring at 2 and 6 months of age. In this study, we examined the effect of prenatal dexamethasone administered daily on days 15 and 16 of gestation in male and female offspring after 1 year of age on glomerular filtration rate. The prenatal dexamethasone male group had a higher systolic blood pressure than the vehicle male group. Females had lower systolic blood pressures than the males and prenatal dexamethasone did not affect blood pressure in female offspring. Prenatal dexamethasone resulted in a reduction in glomerular filtration rate in male but not in female rats. When corrected for body weight, the control male rats had a lower glomerular filtration rate than the control female rats. Males had greater protein excretion than females and prenatal dexamethasone increased the protein excretion only in male rats. Glomerulosclerosis was also greater in male rats than females but was not affected by prenatal dexamethasone. In summary, male rats appear to have evidence of a decline in glomerular filtration rate after 1 year of age and prenatal dexamethasone programs an accelerated decline in glomerular filtration rate in male but not in female offspring.

Aging - physiology

Albuminuria - chemically induced

Animals

Blood Pressure - drug effects

Dexamethasone - administration & dosage

Dexamethasone - toxicity

Drug Administration Schedule

Female

Glomerular Filtration Rate - drug effects

Glucocorticoids - administration & dosage

Glucocorticoids - toxicity

Kidney - drug effects

Kidney - pathology

Male

Pregnancy

Prenatal Exposure Delayed Effects - chemically induced

Prenatal Exposure Delayed Effects - pathology

Proteinuria - chemically induced

Rats, Sprague-Dawley

Sex Factors

Details

Title: Subtitle: Effect of sex on glomerular filtration rate in programmed rats by prenatal dexamethasone
Creators: Jyoti Jain - The University of Texas Southwestern Medical Center
Susan K Legan - The University of Texas Southwestern Medical Center
Issa Alhamoud - The University of Texas Southwestern Medical Center
Jyothsna Gattineni - The University of Texas Southwestern Medical Center
Michel Baum - The University of Texas Southwestern Medical Center
Resource Type: Journal article
Publication Details: Physiological reports, Vol.7(12), pp.e14154-n/a
DOI: 10.14814/phy2.14154
PMID: 31243892
PMCID: PMC6594923
NLM abbreviation: Physiol Rep
ISSN: 2051-817X
eISSN: 2051-817X
Grant note: 1P30DK079328 / NIDDK NIH HHS DK078596 / NIDDK NIH HHS
Language: English
Date published: 07/2019
Academic Unit: Stead Family Department of Pediatrics
Record Identifier: 9984354119202771

Metrics

18 Record Views

9 Times Cited - Web of Science