Journal article
Effect of sucrose ingestion on plasma glutamate concentrations in humans administered monosodium L-glutamate
The American journal of clinical nutrition, Vol.43(4), pp.510-515
04/01/1986
DOI: 10.1093/ajcn/43.4.510
PMID: 2870635
Abstract
Plasma glutamate concentrations in human subjects are markedly lower when monosodium L-glutamate (MSG) is ingested in consomme with starch than when ingested in consomme alone. This study investigated whether sucrose had a similar effect. Six normal adult subjects (three male, three female) ingested two servings of beef consomme each providing 50 mg MSG/kg body weight in a randomized crossover design. One serving of consomme contained no added carbohydrate; the other provided 0.5 g sucrose/kg body weight. Ingestion of the consomme without sucrose significantly (p less than 0.05) increased the mean plasma glutamate concentration from baseline (4.44 +/- 0.97 mumol/dl) to a peak value of 18.1 +/- 6.99 mumol/dl 30 min after dosing. The area under the plasma glutamate concentration-time curve was 553 +/- 238 mumol/dl X min. When the consomme contained 0.5 g sucrose/kg body weight, both the mean peak plasma glutamate concentration (5.48 +/- 2.19 mumol/dl) and the area under the curve (105 +/- 46 mumol/dl X min) were significantly lower. These data confirm that metabolizable carbohydrate has a significant effect on plasma glutamate concentration response after MSG loading.
Details
- Title: Subtitle
- Effect of sucrose ingestion on plasma glutamate concentrations in humans administered monosodium L-glutamate
- Creators
- Lewis D SteginkL. J Filer JrGeorge L BakerEdward F Bell
- Resource Type
- Journal article
- Publication Details
- The American journal of clinical nutrition, Vol.43(4), pp.510-515
- DOI
- 10.1093/ajcn/43.4.510
- PMID
- 2870635
- ISSN
- 0002-9165
- eISSN
- 1938-3207
- Language
- English
- Date published
- 04/01/1986
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology
- Record Identifier
- 9984354044802771
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