Journal article
Effect of sucrose on the metabolic disposition of aspartame
The American journal of clinical nutrition, Vol.52(2), pp.335-341
08/01/1990
DOI: 10.1093/ajcn/52.2.335
PMID: 2197852
Abstract
Twelve normal adult subjects ingested a beverage providing 0.136 mmol aspartame/kg body wt on 2 different days. On 1 study day the beverage provided only aspartame, on the other the beverage provided both aspartame and 3.51 mmol sucrose/kg body wt. The high mean plasma phenylalanine concentrations were similar after administration of aspartame alone (158 ± 28.9 μmol·L, x̄ ± SD) and administration of aspartame plus sucrose (134 ± 44.1 μmol/L). Evaluation of the area under the plasma concentration-time curve (AUC) for phenylalanine also showed no significant difference between groups (197 ± 49.1 vs 182 ± 28.3 μmol/L-1 · h for aspartame alone and aspartame plus sucrose, respectively). Similarly, the high mean ratio of phenylalanine to large neutral amino acids (Phe:LNAA) in plasma did not differ significantly (0.265 ± 0.046 for aspartame alone, 0.275 ± 0.107 for aspartame plus sucrose). However, there was a small but significant difference between groups for the 4-h AUC values for plasma Phe:LNAA. The simultaneous ingestion of sucrose with aspartame had only minor effects on aspartame's metabolic disposition.
Details
- Title: Subtitle
- Effect of sucrose on the metabolic disposition of aspartame
- Creators
- Lewis D Stegink - University of IowaMarvin C Brummel - University of IowaThomas J. Persoon - University of IowaLloyd J Filer Jr - University of IowaEdward F Bell - University of IowaEkhard E Ziegler - University of Iowa
- Resource Type
- Journal article
- Publication Details
- The American journal of clinical nutrition, Vol.52(2), pp.335-341
- DOI
- 10.1093/ajcn/52.2.335
- PMID
- 2197852
- ISSN
- 0002-9165
- eISSN
- 1938-3207
- Language
- English
- Date published
- 08/01/1990
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology
- Record Identifier
- 9984353824702771
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