Journal article
Effect of sympathetic nerves on cerebral vessels during seizures
The American journal of physiology, Vol.237(2), pp.H178-184
08/1979
DOI: 10.1152/ajpheart.1979.237.2.H178
PMID: 464110
Abstract
The purpose of this study was to determine the effect of activation of sympathetic pathways during seizures on cerebral blood flow and integrity of the blood-brain barrier. We measured cerebral blood flow with microspheres and disruption of the blood-brain barrier with labeled albumin in cats. One cerebral hemisphere was denervated by cutting the superior cervical sympathetic trunk on one side. During bicuculline-induced seizures, superior cervical sympathetic nerve activity increased about threefold. Blood flow to the innervated hemibrain was significantly lower than flow to denervated hemibrain. However, in relation to the total increase in flow, this effect of nerves was minor. Blood-brain barrier permeability increased about sixfold during seizures, but there was no difference between the innervated and denervated sides of the brain. We conclude that sympathetic nerves attenuate the increase in cerebral blood flow during seizures, despite the increase in metabolism, but this effect is small. Activation of sympathetic nerves does not reduce disruption of the blood-brain barrier during seizures.
Details
- Title: Subtitle
- Effect of sympathetic nerves on cerebral vessels during seizures
- Creators
- Shirley M MuellerDonald D HeistadMelvin L Marcus
- Resource Type
- Journal article
- Publication Details
- The American journal of physiology, Vol.237(2), pp.H178-184
- DOI
- 10.1152/ajpheart.1979.237.2.H178
- PMID
- 464110
- NLM abbreviation
- Am J Physiol
- ISSN
- 0002-9513
- eISSN
- 2163-5773
- Publisher
- United States
- Language
- English
- Date published
- 08/1979
- Academic Unit
- Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984040482402771
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