Journal article
Effect of the TNF-α–promoter polymorphism on cardiac allograft rejection
The Journal of heart and lung transplantation, Vol.23(6), pp.696-700
2004
DOI: 10.1016/j.healun.2003.07.012
PMID: 15366429
Abstract
A polymorphism exists in the tumor necrosis factor α (TNF-α) promoter (position −308, G/A = TNFA1/TNFA2). The TNFA2 allele is associated with increased TNF-α production in vitro and has been reported to increase the risk of allograft rejection in pediatric recipients of cardiac transplantation. We examined the effect of the TNFA2 allele on the risk of allograft rejection in adult cardiac transplant recipients.
We prospectively analyzed 57 subjects (aged 54 ± 11 years, 84% men, 49% ischemic) who underwent cardiac transplantation between October 1996 and July 2001. Patients were observed after transplantation (mean, 910 ± 605 days) and the frequency of allograft rejection (biopsy Grade ≥2) in patients with the TNFA2 allele (Group A,
n = 15) was compared with TNFA1 homozygotes (Group B,
n = 42). Overall survival and time to rejection episodes also were compared between groups.
The frequency of allograft rejection was similar between groups (Group A, 8/15 [56%]; Group B, 22/42 [52%];
p = 0.77). Time to rejection also was comparable (Group A, 17 ± 11 days; Group B, 20 ± 20 days,
p = 0.74). Overall post-transplant survival was similar between groups (1- and 2-year percentage survival: Group A, 87% and 78%, Group B, 88% and 82%,
p = 0.35).
The TNFA2 allele was not associated with increased risk of rejection in adult cardiac transplant recipients. The impact of this polymorphism on overall post-transplant outcomes will require investigation in larger multicenter studies.
Details
- Title: Subtitle
- Effect of the TNF-α–promoter polymorphism on cardiac allograft rejection
- Creators
- Maninder Bedi - Cardiovascular Institute , University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USALisa A Postava - Cardiovascular Institute , University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USASrinivas Murali - Cardiovascular Institute , University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USAGuy A MacGowan - Cardiovascular Institute , University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USAMichael Mathier - Cardiovascular Institute , University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USALawrence Shears - Division of Cardiothoracic Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USARobert Kormos - Division of Cardiothoracic Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USARichard Holubkov - Department of Family and Preventive Medicine, School of Medicine, University of Utah, Salt Lake City, Utah, USABarry London - Cardiovascular Institute , University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USADennis M McNamara - Cardiovascular Institute , University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
- Resource Type
- Journal article
- Publication Details
- The Journal of heart and lung transplantation, Vol.23(6), pp.696-700
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.healun.2003.07.012
- PMID
- 15366429
- ISSN
- 1053-2498
- eISSN
- 1557-3117
- Language
- English
- Date published
- 2004
- Academic Unit
- Molecular Physiology and Biophysics; Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984025334002771
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