Journal article
Effect of the peroxisome proliferator perfluorodecanoic acid on growth and lipid metabolism in Sprague Dawley rats fed three dietary levels of selenium
Archives of toxicology, Vol.64(1), pp.26-30
01/1990
DOI: 10.1007/BF01973372
PMID: 2306190
Abstract
he possible interrelationships between the effects of dietary selenium and perfluorodecanoic acid (PFDA) on growth and lipid metabolism were studied in the male Sprague Dawley rat. Rats were divided into groups and placed on diets containing three levels of selenium (0.04, 0.2, and 1.0 ppm as sodium selenite). Two weeks later, half the rats in each group received a single 35 mg/kg IP injection of PFDA in corn oil, while their pair-fed companion received only vehicle. Rats injected with PFDA stopped gaining weight, and weighed less than pair-fed controls, despite equal food intakes. Two weeks following PFDA administration the rats were killed and plasma cholesterol and triglycerides, and liver peroxisomal enzyme activities were quantified. In contrast to other peroxisome proliferators, PFDA increased plasma triglycerides while decreasing plasma cholesterol. The rate of peroxisomal fatty acid beta-oxidation was decreased, even though the activity of fatty acyl-CoA oxidase, the first enzyme in the peroxisomal fatty acid beta-oxidation pathway, was increased. Dietary selenium, other than increasing the liver to body weight ratio, did not alter growth or lipid metabolism. This study demonstrates, for the first time, the existence of a "non-hypotriglyceridemic" peroxisome proliferator - PFDA.
Details
- Title: Subtitle
- Effect of the peroxisome proliferator perfluorodecanoic acid on growth and lipid metabolism in Sprague Dawley rats fed three dietary levels of selenium
- Creators
- Tim BorgesHoward P GlauertLi -Chuan ChenChing K ChowLarry W Robertson
- Resource Type
- Journal article
- Publication Details
- Archives of toxicology, Vol.64(1), pp.26-30
- DOI
- 10.1007/BF01973372
- PMID
- 2306190
- ISSN
- 0340-5761
- eISSN
- 1432-0738
- Language
- English
- Date published
- 01/1990
- Academic Unit
- Occupational and Environmental Health
- Record Identifier
- 9984002435402771
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