Effect of thigh strength on incident radiographic and symptomatic knee osteoarthritis in a longitudinal cohort

Neil A Segal; James C Torner; David Felson; Jingbo Niu; Leena Sharma; Cora E Lewis; Michael Nevitt

doi:10.1002/art.24541

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Effect of thigh strength on incident radiographic and symptomatic knee osteoarthritis in a longitudinal cohort

Journal article

Open access

Peer reviewed

Effect of thigh strength on incident radiographic and symptomatic knee osteoarthritis in a longitudinal cohort

Neil A Segal, James C Torner, David Felson, Jingbo Niu, Leena Sharma, Cora E Lewis and Michael Nevitt

Arthritis and rheumatism, Vol.61(9), pp.1210-1217

09/15/2009

DOI: 10.1002/art.24541

PMCID: PMC2830551

PMID: 19714608

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Abstract

To assess whether knee extensor strength or hamstring:quadriceps (H:Q) ratio predicts risk for incident radiographic tibiofemoral and incident symptomatic whole knee osteoarthritis (OA) in adults ages 50-79 years. We followed 1,617 participants (2,519 knees) who, at the baseline visit of the Multicenter Osteoarthritis (MOST) Study, did not have radiographic tibiofemoral OA and 2,078 participants (3,392 knees) who did not have symptomatic whole knee OA (i.e., did not have the combination of radiographic OA and frequent knee symptoms). Isokinetic strength was measured at baseline, and participants were followed for development of incident radiographic tibiofemoral OA, or incident symptomatic whole knee OA at 30 months. Generalized estimating equations accounted for 2 knees per subject, and multivariable models adjusted for age, body mass index (BMI), hip bone mineral density, knee surgery or pain, and physical activity score. In the studies of incident radiographic and incident symptomatic knee OA, mean +/- SD ages were 62.4 +/- 8.0 years and 62.3 +/- 8.0 years, respectively, and mean +/- SD BMI scores were 30.6 +/- 5.8 kg/m(2) and 30.2 +/- 5.5 kg/m(2), respectively. Knee extensor strength and H:Q ratio at baseline significantly differed between men and women. Neither knee extensor strength nor the H:Q ratio was predictive of incident radiographic tibiofemoral OA. Compared with the lowest tertile, the highest tertile of knee extensor strength protected against development of incident symptomatic whole knee OA in both sexes (adjusted odds ratio 0.5-0.6). H:Q ratio was not predictive of incident symptomatic whole knee OA in either sex. Thigh muscle strength does not appear to predict incident radiographic OA, but does seem to predict incident symptomatic knee OA.

Body Mass Index

Multivariate Analysis

Prospective Studies

Bone Density - physiology

Humans

Middle Aged

Risk Factors

Tibia - diagnostic imaging

Male

Femur - diagnostic imaging

Osteoarthritis, Knee - epidemiology

Osteoarthritis, Knee - diagnostic imaging

Incidence

Radiography

Female

Aged

Osteoarthritis, Knee - physiopathology

Longitudinal Studies

Cohort Studies

Muscle Strength - physiology

Thigh - physiopathology

Details

Title: Subtitle: Effect of thigh strength on incident radiographic and symptomatic knee osteoarthritis in a longitudinal cohort
Creators: Neil A Segal - University of Iowa, Iowa City. USA. neil.segal@uiowa.edu
James C Torner
David Felson
Jingbo Niu
Leena Sharma
Cora E Lewis
Michael Nevitt
Resource Type: Journal article
Publication Details: Arthritis and rheumatism, Vol.61(9), pp.1210-1217
DOI: 10.1002/art.24541
PMID: 19714608
PMCID: PMC2830551
NLM abbreviation: Arthritis Rheum
ISSN: 0004-3591
eISSN: 1529-0131
Publisher: United States
Grant note: U01 AG018947 / NIA NIH HHS U01 AG018832 / NIA NIH HHS K12 HD001097 / NICHD NIH HHS U01 AG18947 / NIA NIH HHS U01 AG18832 / NIA NIH HHS U01 AG018832-08 / NIA NIH HHS U01 AG019069 / NIA NIH HHS U01 AG18820 / NIA NIH HHS U01 AG19069 / NIA NIH HHS U01 AG018820 / NIA NIH HHS
Language: English
Date published: 09/15/2009
Academic Unit: Epidemiology; Surgery; Injury Prevention Research Center; Neurosurgery
Record Identifier: 9983995104402771

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