Effect of topical vaginal products on the detection of prostate-specific antigen, a biomarker of semen exposure, using ABAcards

Margaret C. Snead; Athena P. Kourtis; Carolyn M. Black; Christine K. Mauck; Teresa M. Brown; Ana Penman-Aguilar; Johan H. Melendez; Maria F. Gallo; Denise J. Jamieson; Maurizio Macaluso

doi:10.1016/j.contraception.2012.10.034

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Effect of topical vaginal products on the detection of prostate-specific antigen, a biomarker of semen exposure, using ABAcards

Journal article

Open access

Peer reviewed

Effect of topical vaginal products on the detection of prostate-specific antigen, a biomarker of semen exposure, using ABAcards

Margaret C. Snead, Athena P. Kourtis, Carolyn M. Black, Christine K. Mauck, Teresa M. Brown, Ana Penman-Aguilar, Johan H. Melendez, Maria F. Gallo, Denise J. Jamieson and Maurizio Macaluso

Contraception (Stoneham), Vol.88(3), pp.382-386

09/01/2013

DOI: 10.1016/j.contraception.2012.10.034

PMCID: PMC4547343

PMID: 23218862

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https://www.ncbi.nlm.nih.gov/pmc/articles/4547343View

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Abstract

Prostate-specific antigen (PSA) is a biomarker of recent semen exposure. There is currently only limited information on whether topical vaginal products affect PSA assays. We investigated this question using various dilutions of several vaginal products (lubricants and spermicides) and the Abacus ABAcard for PSA detection. Pooled semen controls and various dilutions of nonoxynol-9 (N9), carboxymethyl cellulose (CMC), Replens, Gynol 2, K-Y jelly, Astroglide, Surgilube, combined with pooled semen dilutions, were tested for PSA using the Abacus ABAcard. N9 (2% with saline) and CMC did not appear to affect the results of testing with the ABAcard, but not all semen dilutions were tested. The other products (including Replens and Gynol, which is 2% N9 with propylene glycol, K-Y, Astroglide and Surgilube) at some of the dilutions tested either affected or gave invalid results with PSA testing using the ABAcard. Both Gynol 2 and K-Y at 1:10 dilution gave false-positive results. Some vaginal products affect PSA results obtained by using the semiquantitative ABAcard. In vivo confirmation is necessary to further optimize PSA detection when topical vaginal products are present.

ABAcard

Biomarker

Lubricants

PSA

Semen

Spermicide

Vaginal products

Details

Title: Subtitle: Effect of topical vaginal products on the detection of prostate-specific antigen, a biomarker of semen exposure, using ABAcards
Creators: Margaret C. Snead - National Center for Chronic Disease Prevention and Health Promotion
Athena P. Kourtis - Centers for Disease Control and Prevention
Carolyn M. Black - National Center for Emerging and Zoonotic Infectious Diseases
Christine K. Mauck - Eastern Virginia Medical School
Teresa M. Brown - National Center for Emerging and Zoonotic Infectious Diseases
Ana Penman-Aguilar - National Center for Chronic Disease Prevention and Health Promotion
Johan H. Melendez - Johns Hopkins University
Maria F. Gallo - National Center for Chronic Disease Prevention and Health Promotion
Denise J. Jamieson - Centers for Disease Control and Prevention
Maurizio Macaluso - Cincinnati Children's Hospital Medical Center
Resource Type: Journal article
Publication Details: Contraception (Stoneham), Vol.88(3), pp.382-386
DOI: 10.1016/j.contraception.2012.10.034
PMID: 23218862
PMCID: PMC4547343
NLM abbreviation: Contraception
ISSN: 0010-7824
eISSN: 1879-0518
Publisher: Elsevier Inc
Language: English
Date published: 09/01/2013
Academic Unit: Obstetrics and Gynecology; VPMA - Administration
Record Identifier: 9984446525902771

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