Journal article
Effect of ultra-low-dose transdermal estradiol on breast density in postmenopausal women
Menopause (New York, N.Y.), Vol.14(3), pp.391-396
05/01/2007
DOI: 10.1097/01.gme.0000236939.81819.6c
PMID: 17224859
Abstract
Objective: Women with higher mammographic breast density have increased risk for breast cancer, and there is some evidence that a change in breast density may be a marker for change in risk for breast cancer. The purpose of this study was to determine whether 2 years of treatment with ultra-low-dose transdermal estradiol results in a change in breast density
Design: The Ultra-Low-dose Transdermal Estradiol Assessment was a randomized, blinded, placebo-controlled trial of 2 years of treatment with unopposed ultra-low-dose (0.014 mg/d) transdermal estradiol for prevention of osteoporosis in 417 postmenopausal women with no history of breast cancer who had not had a hysterectomy. We obtained mammograms at baseline and after I and 2 years of treatment from 276 of the participants. Right craniocaudal views were analyzed at a central radiology facility by a trained clinician blinded to treatment group and order of acquisition. Contour analysis was performed to define dense areas versus fatty tissue. Between-group differences in mean change in percent breast density from baseline to I and to 2 years of follow-up were assessed using linear regression models adjusted for clinical site.
Results: Participants were 66 5 years old and 94% were white. The average percent breast density at baseline was 34%. There was no significant difference between treatment groups in change in percent breast density after 1 year (between-group difference, 0.1%; 95% confidence interval, -1.3% to 1.6%) or 2 years of treatment (0.8%; -0.6% to 2.1%).
Conclusions: Two years of treatment with ultra-low-dose transdermal estradiol did not increase breast density.
Details
- Title: Subtitle
- Effect of ultra-low-dose transdermal estradiol on breast density in postmenopausal women
- Creators
- Deborah Grady - University of California Women's Health Clinical Research Center, San Francisco, CA 94115, USA.Eric Vittinghoff - University of California, San FranciscoFeng Lin - University of California, San FranciscoVladimir Hanes - BayerKristine Ensrud - United States Department of Veterans AffairsLaurel A. Habel - Kaiser PermanenteRobert Wallace - University of IowaJudith Macer - University of California, San FranciscoSteven R. Cummings - University of California, San FranciscoJohn Shepherd - University of California, San Francisco
- Resource Type
- Journal article
- Publication Details
- Menopause (New York, N.Y.), Vol.14(3), pp.391-396
- DOI
- 10.1097/01.gme.0000236939.81819.6c
- PMID
- 17224859
- NLM abbreviation
- Menopause
- ISSN
- 1072-3714
- eISSN
- 1530-0374
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 6
- Language
- English
- Date published
- 05/01/2007
- Academic Unit
- Epidemiology; Injury Prevention Research Center; Internal Medicine
- Record Identifier
- 9984364399502771
Metrics
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