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Effect of upper respiratory infection on anaesthesia induced atelectasis in paediatric patients
Journal article   Peer reviewed

Effect of upper respiratory infection on anaesthesia induced atelectasis in paediatric patients

Hye-Mi Lee, Hyo-Jin Byon, Namo Kim, Stephen J Gleich, Randall P Flick and Jeong-Rim Lee
Scientific reports, Vol.11(1), pp.5981-5981
03/16/2021
DOI: 10.1038/s41598-021-85378-0
PMCID: PMC7966804
PMID: 33727626

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Abstract

Upper respiratory tract infection (URI) symptoms are known to increase perioperative respiratory adverse events (PRAEs) in children undergoing general anaesthesia. General anaesthesia per se also induces atelectasis, which may worsen with URIs and yield detrimental outcomes. However, the influence of URI symptoms on anaesthesia-induced atelectasis in children has not been investigated. This study aimed to demonstrate whether current URI symptoms induce aggravation of perioperative atelectasis in children. Overall, 270 children aged 6 months to 6 years undergoing surgery were prospectively recruited. URI severity was scored using a questionnaire and the degree of atelectasis was defined by sonographic findings showing juxtapleural consolidation and B-lines. The correlation between severity of URI and degree of atelectasis was analysed by multiple linear regression. Overall, 256 children were finally analysed. Most children had only one or two mild symptoms of URI, which were not associated with the atelectasis score across the entire cohort. However, PRAE occurrences showed significant correspondence with the URI severity (odds ratio 1.36, 95% confidence interval 1.10-1.67, p = 0.004). In conclusion, mild URI symptoms did not exacerbate anaesthesia-induced atelectasis, though the presence and severity of URI were correlated with PRAEs in children.Trial registration: Clinicaltrials.gov (NCT03355547).
 Age Factors Anesthesia, General - adverse effects Anesthesia, General - methods Child Child, Preschool Disease Management Disease Susceptibility Female Humans Infant Male Odds Ratio Pulmonary Atelectasis - diagnosis Pulmonary Atelectasis - etiology Pulmonary Atelectasis - therapy Respiratory Tract Infections - complications Respiratory Tract Infections - diagnosis Symptom Assessment Treatment Outcome Ultrasonography

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