Journal article
Effect of varying frequency, intensity, and pulse duration of transcutaneous electrical nerve stimulation on primary hyperalgesia in inflamed rats
Archives of physical medicine and rehabilitation, Vol.81(7), pp.984-990
07/2000
DOI: 10.1053/apmr.2000.5576
PMID: 10896017
Abstract
Gopalkrishnan P, Sluka KA. Effect of varying frequency, intensity, and pulse duration of transcutaneous electrical nerve stimulation on primary hyperalgesia in inflamed rats. Arch Phys Med Rehabil 2000;81:984-90. Objectives: To examine the effect of varying frequency, intensity, and pulse duration of transcutaneous electrical nerve stimulation (TENS) on primary hyperalgesia (increased response to a noxious stimuli) to heat and mechanical stimuli induced by carrageenan paw inflammation in rats. Design: Inflammation was induced by injection of 3% carrageenan into the hindpaw. Two frequencies (high, 100Hz; low, 4Hz), 2 intensities (high, motor; low, sensory), and 2 pulse durations (100μsec, 250μsec) were applied for 20 minutes to the inflamed paw. The paw withdrawal latency (PWL) to radiant heat, threshold to mechanical stimuli, and spontaneous pain-related behaviors were measured before and 4 hours after induction of inflammation, after TENS, and at 8, 12, and 24 hours after inflammation. A 3-factor (frequency, intensity, pulse duration) repeated-measures (time) design was used to analyze the changes in PWL. Mechanical threshold and spontaneous pain-related behaviors were compared for frequency, intensity, and pulse duration with a Kruskal-Wallis analysis of variance. Results: For changes in PWL to heat, there was an effect for time (p =.0001) and frequency (p =.0001), but not for intensity (p =.45) or pulse duration (p =.21). For changes in mechanical threshold, there was also an effect for frequency (p =.007), but not for intensity (p =.055) or pulse duration (p =.058), after treatment with TENS. High-frequency TENS significantly reduced the primary hyperalgesia to heat and mechanical stimuli when compared with controls receiving no TENS or treatment with low-frequency TENS. High-frequency motor TENS also reduced spontaneous pain-related behaviors for 1 day after treatment. Conclusion: High-frequency TENS reduces primary hyperalgesia to heat and mechanical stimuli for up to 1 day after treatment. In contrast, low-frequency TENS is ineffective in reducing primary hyperalgesia. Varying intensity or pulse duration had no effect on the degree of antihyperalgesia produced by high-frequency TENS. © 2000 by the American Congress of Rehabilitation Medicine and the American Academy of Physical Medicine and Rehabilitation
Details
- Title: Subtitle
- Effect of varying frequency, intensity, and pulse duration of transcutaneous electrical nerve stimulation on primary hyperalgesia in inflamed rats
- Creators
- Priya GopalkrishnanKathleen A Sluka
- Resource Type
- Journal article
- Publication Details
- Archives of physical medicine and rehabilitation, Vol.81(7), pp.984-990
- DOI
- 10.1053/apmr.2000.5576
- PMID
- 10896017
- NLM abbreviation
- Arch Phys Med Rehabil
- ISSN
- 0003-9993
- eISSN
- 1532-821X
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 07/2000
- Academic Unit
- Iowa Neuroscience Institute; Nursing; Physical Therapy and Rehabilitation Science; Neuroscience and Pharmacology
- Record Identifier
- 9984040350002771
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