Journal article
Effect on ribonucleotide reductase of novel lipophilic iron chelators: the desferri-exochelins
Biochemical and biophysical research communications, Vol.315(3), pp.595-598
03/12/2004
DOI: 10.1016/j.bbrc.2004.01.101
PMID: 14975742
Abstract
Desferri-exochelins are siderophores secreted by
Mycobacterium tuberculosis that are both lipid- and water-soluble and have a high binding affinity for iron. Desferri-exochelin 772SM inhibits DNA replication and ribonucleotide reductase activity at 10-fold less concentration than the lipid-insoluble iron chelator deferoxamine, which is currently in clinical use. Neither chelator can extract iron directly from ribonucleotide reductase. However, because of its lipid-solubility and high binding affinity, desferri-exochelin is able to enter cells rapidly and access intracellular iron, while deferoxamine has limited capacity to cross the cell membrane.
Details
- Title: Subtitle
- Effect on ribonucleotide reductase of novel lipophilic iron chelators: the desferri-exochelins
- Creators
- Yvonne K Hodges - University of Colorado HealthWilliam E Antholine - Medical College of WisconsinLawrence D Horwitz - University of Colorado Health
- Resource Type
- Journal article
- Publication Details
- Biochemical and biophysical research communications, Vol.315(3), pp.595-598
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.bbrc.2004.01.101
- PMID
- 14975742
- ISSN
- 0006-291X
- eISSN
- 1090-2104
- Language
- English
- Date published
- 03/12/2004
- Academic Unit
- Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984656603902771
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