Effective targeting of PDGFRA-altered high-grade glioma with avapritinib

We thank Leonie Mikael for the helpful review of the manuscript. We acknowledge the support of Antony Hsieh, Mikael L. Rinne, Nina Perez, Sasa Dimitrijevic, and Sean Kim from Blueprint Medicines Corporation for their involvement in human avapritinib pharmacokinetic data generation and their review of this manuscript. We further thank Georg Schrockenfuchs, Dominik Kirchhofer, Carola Jaunecker, and Johannes Hainfellner for their support of this study. Several figures were created with BioRender.com . This work was supported by Sajni Chakrabarti Fund for Pediatric Brain Cancer Research (M.G.F.) , Caroline Mortimer Fund (M.G.F.) , DMG Precision Medicine Collaborative (M.G.F.) , Claudia Adams Barr Program (M.G.F.) , Cuming Family Fund for Pediatric Brain Tumor Research (M.G.F.) , Anita, Sophia, and Athena Fund to Advance DIPG Research and Care (M.G.F.) , Liv Like A Unicorn (M.G.F.) , We love you Connie Fund (M.G.F.) , MaleiaStrong Foundation (M.G.F.) , The Morris Family (M.G.F.) and the DIPG All-In Initiative (M.G.F.) . M.G.F. holds a NIH Director's New Innovator Award (DP2NS127705) , a Career Award for Medical Scientist from the Burroughs Wellcome Fund, the Distinguished Scientist Award from the Sontag Foundation, the Helen Gurley Brown Foundation Helen Gurley Brown Presidential Initiative at Dana-Farber Cancer Institute, and the A-Award from the Alex's Lemonade Stand Foundation. M.G.F. was also supported by National Cancer Institute SPORE grant P50CA165962 and by National Cancer Institute U54 grant CA274516. C.K. was supported by National Institutes of Health Grant R01-NS119231 and R01-NS124607, DOD Grant CA201129P1, University of Michigan Chad Carr Pediatric Brain Tumor Center, Evans Family, ChadTough Defeat DIPG Foundation, Catching Up with Jack, Pediatric Brain Tumor Foundation, Michael Miller Memorial Foundation, Morgan Behen Golf Classic, and Yuvaan Tiwari Foundation. J.G. was supported by Forschungsgesellschaft fuer cerebrale Tumore and Verein unser_kind. Other funding sources were Physician Researcher Pathway Scholarship of the Medical University of Vienna (L.M.) , the Medical-scientific fund of the Mayor of the federal capital Vienna (project #19086, L.M.) , the Austrian Science Fund (project T906-B28 to D.L.G. and P30105 to W.B.) , Ministry of Health of the Czech Republic (Grant number NU20-03-00240; H.P., O.S., J.S.) , and Walter Benjamin Program of the German Research Foundation (S.N.) . C.J. was supported by Cancer Research UK, CRIS Cancer Foundation and Brain Tumour Research.