Journal article
Effectiveness of Monovalent mRNA COVID-19 Vaccination in Preventing COVID-19-Associated Invasive Mechanical Ventilation and Death Among Immunocompetent Adults During the Omicron Variant Period - IVY Network, 19 U.S. States, February 1, 2022-January 31, 2023
MMWR. Morbidity and mortality weekly report, Vol.72(17), pp.463-468
04/28/2023
DOI: 10.15585/mmwr.mm7217a3
PMID: 37104244
Abstract
As of April 2023, the COVID-19 pandemic has resulted in 1.1 million deaths in the United States, with approximately 75% of deaths occurring among adults aged ≥65 years (1). Data on the durability of protection provided by monovalent mRNA COVID-19 vaccination against critical outcomes of COVID-19 are limited beyond the Omicron BA.1 lineage period (December 26, 2021-March 26, 2022). In this case-control analysis, the effectiveness of 2-4 monovalent mRNA COVID-19 vaccine doses was evaluated against COVID-19-associated invasive mechanical ventilation (IMV) and in-hospital death among immunocompetent adults aged ≥18 years during February 1, 2022-January 31, 2023. Vaccine effectiveness (VE) against IMV and in-hospital death was 62% among adults aged ≥18 years and 69% among those aged ≥65 years. When stratified by time since last dose, VE was 76% at 7-179 days, 54% at 180-364 days, and 56% at ≥365 days. Monovalent mRNA COVID-19 vaccination provided substantial, durable protection against IMV and in-hospital death among adults during the Omicron variant period. All adults should remain up to date with recommended COVID-19 vaccination to prevent critical COVID-19-associated outcomes.
Details
- Title: Subtitle
- Effectiveness of Monovalent mRNA COVID-19 Vaccination in Preventing COVID-19-Associated Invasive Mechanical Ventilation and Death Among Immunocompetent Adults During the Omicron Variant Period - IVY Network, 19 U.S. States, February 1, 2022-January 31, 2023
- Creators
- Jennifer DeCuirDiya SurieYuwei ZhuManjusha GaglaniAdit A GindeDavid J DouinH Keipp TalbotJonathan D CaseyNicholas M MohrTresa McNealShekhar GhamandeKevin W GibbsD Clark FilesDavid N HagerMinh PhanMatthew E PrekkerMichelle N GongAmira MohamedNicholas J JohnsonJay S SteingrubIthan D PeltanSamuel M BrownEmily T MartinArnold S MontoAkram KhanWilliam S BenderAbhijit DuggalJennifer G WilsonNida QadirSteven Y ChangChristopher MallowJennie H KwonMatthew C ExlineAdam S LauringNathan I ShapiroCristie ColumbusRobert GottliebIvana A VaughnMayur RameshLois E LameratoBasmah SafdarNatasha HalasaJames D ChappellCarlos G GrijalvaAdrienne BaughmanKelsey N WomackJillian P RhoadsKimberly W HartSydney A SwanNathaniel LewisMeredith L McMorrowWesley H SelfIVY Network
- Resource Type
- Journal article
- Publication Details
- MMWR. Morbidity and mortality weekly report, Vol.72(17), pp.463-468
- DOI
- 10.15585/mmwr.mm7217a3
- PMID
- 37104244
- NLM abbreviation
- MMWR Morb Mortal Wkly Rep
- ISSN
- 0149-2195
- eISSN
- 1545-861X
- Grant note
- K23 GM129661 / NIGMS NIH HHS
- Language
- English
- Date published
- 04/28/2023
- Academic Unit
- Epidemiology; Emergency Medicine; Anesthesia; Injury Prevention Research Center
- Record Identifier
- 9984399495402771
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