Journal article
Effectiveness of a Third Dose of Pfizer-BioNTech and Moderna Vaccines in Preventing COVID-19 Hospitalization Among Immunocompetent and Immunocompromised Adults - United States, August-December 2021
MMWR. Morbidity and mortality weekly report, Vol.71(4), pp.118-124
01/28/2022
DOI: 10.15585/mmwr.mm7104a2
PMCID: PMC9351530
PMID: 35085218
Abstract
COVID-19 mRNA vaccines (BNT162b2 [Pfizer-BioNTech] and mRNA-1273 [Moderna]) provide protection against infection with SARS-CoV-2, the virus that causes COVID-19, and are highly effective against COVID-19–associated hospitalization among eligible persons who receive 2 doses (1,2). However, vaccine effectiveness (VE) among persons with immunocompromising conditions* is lower than that among immunocompetent persons (2), and VE declines after several months among all persons (3). On August 12, 2021, the Food and Drug Administration (FDA) issued an emergency use authorization (EUA) for a third mRNA vaccine dose as part of a primary series ≥28 days after dose 2 for persons aged ≥12 years with immunocompromising conditions, and, on November 19, 2021, as a booster dose for all adults aged ≥18 years at least 6 months after dose 2, changed to ≥5 months after dose 2 on January 3, 2022 (4,5,6). Among 2,952 adults (including 1,385 COVID-19 case-patients and 1,567 COVID-19–negative controls) hospitalized at 21 U.S. hospitals during August 19– December 15, 2021, effectiveness of mRNA vaccines against COVID-19–associated hospitalization was compared between adults eligible for but who had not received a third vaccine dose (1,251) and vaccine-eligible adults who received a third dose ≥7 days before illness onset (312). Among 1,875 adults without immunocompromising conditions (including 1,065 [57%] unvaccinated, 679 [36%] 2-dose recipients, and 131 [7%] 3-dose [booster] recipients), VE against COVID-19
Details
- Title: Subtitle
- Effectiveness of a Third Dose of Pfizer-BioNTech and Moderna Vaccines in Preventing COVID-19 Hospitalization Among Immunocompetent and Immunocompromised Adults - United States, August-December 2021
- Creators
- Mark W. TenfordeManish M. PatelManjusha Gaglani - Baylor Medical Center at GarlandAdit A. Ginde - University of Colorado HospitalDavid J. Douin - University of Colorado HospitalH. Keipp Talbot - Vanderbilt UniversityJonathan D. Casey - Vanderbilt UniversityNicholas M. Mohr - Univ Iowa, Iowa City, IA USAAnne Zepeski - Univ Iowa, Iowa City, IA USATresa McNeal - Baylor Medical Center at GarlandShekhar Ghamande - Baylor Medical Center at GarlandKevin W. Gibbs - Wake Forest UniversityD. Clark Files - Wake Forest UniversityDavid N. Hager - Johns Hopkins UniversityArber Shehu - Johns Hopkins UniversityMatthew E. Prekker - Hennepin Cty Med Ctr, Minneapolis, MN 55415 USAHeidi L. Erickson - Hennepin Cty Med Ctr, Minneapolis, MN 55415 USAMichelle N. Gong - Albert Einstein College of MedicineAmira Mohamed - Albert Einstein College of MedicineNicholas J. Johnson - University of WashingtonVasisht Srinivasan - University of WashingtonJay S. Steingrub - Baystate Med Ctr, Springfield, MA USAIthan D. Peltan - Intermt Med Ctr, Salt Lake City, UT USASamuel M. Brown - Intermt Med Ctr, Salt Lake City, UT USAEmily T. Martin - University of Michigan Medical SchoolArnold S. Monto - University of Michigan Medical SchoolAkram Khan - Oregon Hlth & Sci Univ Hosp, Portland, OR USACatherine L. Hough - Oregon Hlth & Sci Univ Hosp, Portland, OR USALaurence W. Busse - Emory UniversityAbhijit Duggal - Cleveland Clin, Cleveland, OH 44106 USAJennifer G. Wilson - Stanford UniversityNida Qadir - Ronald Reagan UCLA Med Ctr, Los Angeles, CA USASteven Y. Chang - Ronald Reagan UCLA Med Ctr, Los Angeles, CA USAChristopher Mallow - Univ Miami, Miami, FL USACarolina Rivas - Univ Miami, Miami, FL USAHilary M. Babcock - Washington Univ, St Louis, MO 63110 USAJennie H. Kwon - Washington Univ, St Louis, MO 63110 USAMatthew C. Exline - Ohio State Univ, Wexner Med Ctr, Columbus, OH 43210 USAMena Botros - Ohio State Univ, Wexner Med Ctr, Columbus, OH 43210 USAAdam S. Lauring - University of MichiganNathan Shapiro - Beth Israel Deaconess Med Ctr, Boston, MA 02215 USANatasha Halasa - Vanderbilt UniversityJames D. Chappell - Vanderbilt UniversityCarlos G. Grijalva - Vanderbilt UniversityTodd W. Rice - Vanderbilt UniversityIan D. Jones - Vanderbilt UniversityWilliam B. Stubblefield - Vanderbilt UniversityAdrienne Baughman - Vanderbilt UniversityKelsey N. Womack - Vanderbilt UniversityJillian P. Rhoads - Vanderbilt UniversityChristopher J. Lindsell - Vanderbilt UniversityKimberly W. Hart - Vanderbilt UniversityYuwei Zhu - Vanderbilt UniversityEric A. NaiotiKatherine AdamsNathaniel M. LewisDiya SurieMeredith L. McMorrowWesley H. Self - Vanderbilt UniversityIVY Network
- Resource Type
- Journal article
- Publication Details
- MMWR. Morbidity and mortality weekly report, Vol.71(4), pp.118-124
- DOI
- 10.15585/mmwr.mm7104a2
- PMID
- 35085218
- PMCID
- PMC9351530
- NLM abbreviation
- MMWR Morb Mortal Wkly Rep
- ISSN
- 0149-2195
- eISSN
- 1545-861X
- Publisher
- Centers Disease Control & Prevention
- Number of pages
- 7
- Language
- English
- Date published
- 01/28/2022
- Academic Unit
- Epidemiology; Emergency Medicine; Anesthesia; Injury Prevention Research Center
- Record Identifier
- 9984296137102771
Metrics
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