Effectiveness of mRNA Vaccines Against COVID-19 Hospitalization by Age and Chronic Medical Conditions Burden Among Immunocompetent US Adults, March-August 2021

Nathaniel M. Lewis; Eric A. Naioti; Wesley H. Self; Adit A. Ginde; David J. Douin; H. Keipp Talbot; Jonathan D. Casey; Nicholas M. Mohr; Anne Zepeski; Manjusha Gaglani; Shekhar A. Ghamande; Tresa A. McNeal; Nathan Shapiro; Kevin W. Gibbs; D. Clark Files; David N. Hager; Arber Shehu; Matthew E. Prekker; Heidi L. Erickson; Michelle N. Gong; Amira Mohamed; Daniel J. Henning; Jay S. Steingrub; Ithan D. Peltan; Samuel M. Brown; Emily T. Martin; Kinsley Hubel; Catherine L. Hough; Laurence W. Busse; Caitlin C. ten Lohuis; Abhijit Duggal; Jennifer G. Wilson; Alexandra J. Gordon; Nida Qadir; Steven Y. Chang; Christopher Mallow; Carolina Rivas; Hilary M. Babcock; Jennie H. Kwon; Matthew C. Exline; Natasha Halasa; James D. Chappell; Adam S. Lauring; Carlos G. Grijalva; Todd W. Rice; Jillian P. Rhoads; William B. Stubblefield; Adrienne Baughman; Kelsey N. Womack; Christopher J. Lindsell; Kimberly W. Hart; Yuwei Zhu; Stephanie J. Schrag; Miwako Kobayashi; Jennifer R. Verani; Manish M. Patel; Mark W. Tenforde; IVY Network Collaborators

doi:10.1093/infdis/jiab619

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Effectiveness of mRNA Vaccines Against COVID-19 Hospitalization by Age and Chronic Medical Conditions Burden Among Immunocompetent US Adults, March-August 2021

Journal article

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Peer reviewed

Effectiveness of mRNA Vaccines Against COVID-19 Hospitalization by Age and Chronic Medical Conditions Burden Among Immunocompetent US Adults, March-August 2021

Nathaniel M. Lewis, Eric A. Naioti, Wesley H. Self, Adit A. Ginde, David J. Douin, H. Keipp Talbot, Jonathan D. Casey, Nicholas M. Mohr, Anne Zepeski, Manjusha Gaglani, …

The Journal of infectious diseases, Vol.225(10), pp.1694-1700

12/21/2021

DOI: 10.1093/infdis/jiab619

PMCID: PMC9113447

PMID: 34932114

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Abstract

Vaccine effectiveness (VE) against COVID-19 hospitalization was evaluated among immunocompetent adults (>= 18 years) during March-August 2021 using a case-control design. Among 1669 hospitalized COVID-19 cases (11% fully vaccinated) and 1950 RT-PCR-negative controls (54% fully vaccinated), VE was 96% (95% confidence interval [CI], 93%-98%) among patients with no chronic medical conditions and 83% (95% CI, 76%-88%) among patients with >= 3 categories of conditions. VE was similar between those aged 18-64 years versus >= 65 years (P > .05). VE against severe COVID-19 was very high among adults without chronic conditions and lessened with increasing comorbidity burden.

Immunology

Infectious Diseases

Microbiology

Life Sciences & Biomedicine

Science & Technology

Details

Title: Subtitle: Effectiveness of mRNA Vaccines Against COVID-19 Hospitalization by Age and Chronic Medical Conditions Burden Among Immunocompetent US Adults, March-August 2021
Creators: Nathaniel M. Lewis - Centers for Disease Control and Prevention
Eric A. Naioti - Centers for Disease Control and Prevention
Wesley H. Self - Vanderbilt University Medical Center
Adit A. Ginde - University of Colorado Denver
David J. Douin - University of Colorado Denver
H. Keipp Talbot - Vanderbilt University Medical Center
Jonathan D. Casey - Vanderbilt University Medical Center
Nicholas M. Mohr - University of Iowa
Anne Zepeski - University of Iowa
Manjusha Gaglani - Baylor Medical Center at Garland
Shekhar A. Ghamande - Baylor Medical Center at Garland
Tresa A. McNeal - Baylor Medical Center at Garland
Nathan Shapiro - Beth Israel Deaconess Medical Center
Kevin W. Gibbs - Atrium Health Wake Forest Baptist
D. Clark Files - Atrium Health Wake Forest Baptist
David N. Hager - Johns Hopkins Hospital
Arber Shehu - Johns Hopkins Hospital
Matthew E. Prekker - Hennepin County Medical Center
Heidi L. Erickson - Hennepin County Medical Center
Michelle N. Gong - Albert Einstein College of Medicine
Amira Mohamed - Albert Einstein College of Medicine
Daniel J. Henning - University of Washington
Jay S. Steingrub - Baystate Medical Center
Ithan D. Peltan - Intermountain Medical Center
Samuel M. Brown - Intermountain Medical Center
Emily T. Martin - University of Michigan
Kinsley Hubel - Oregon Health & Science University
Catherine L. Hough - Oregon Health & Science University
Laurence W. Busse - Emory University
Caitlin C. ten Lohuis - Emory University
Abhijit Duggal - Cleveland Clinic
Jennifer G. Wilson - Stanford University
Alexandra J. Gordon - Stanford University
Nida Qadir - Ronald Reagan UCLA Medical Center
Steven Y. Chang - Ronald Reagan UCLA Medical Center
Christopher Mallow - University of Miami
Carolina Rivas - University of Miami
Hilary M. Babcock - Washington University in St. Louis
Jennie H. Kwon - Washington University in St. Louis
Matthew C. Exline - The Ohio State University Wexner Medical Center
Natasha Halasa - Vanderbilt University Medical Center
James D. Chappell - Vanderbilt University Medical Center
Adam S. Lauring - University of Michigan
Carlos G. Grijalva - Vanderbilt University Medical Center
Todd W. Rice - Vanderbilt University Medical Center
Jillian P. Rhoads - Vanderbilt University Medical Center
William B. Stubblefield - Vanderbilt University Medical Center
Adrienne Baughman - Vanderbilt University Medical Center
Kelsey N. Womack - Vanderbilt University Medical Center
Christopher J. Lindsell - Vanderbilt University Medical Center
Kimberly W. Hart - Vanderbilt University Medical Center
Yuwei Zhu - Vanderbilt University Medical Center
Stephanie J. Schrag - Centers for Disease Control and Prevention
Miwako Kobayashi - Centers for Disease Control and Prevention
Jennifer R. Verani - Centers for Disease Control and Prevention
Manish M. Patel - Centers for Disease Control and Prevention
Mark W. Tenforde - Centers for Disease Control and Prevention
IVY Network Collaborators
Resource Type: Journal article
Publication Details: The Journal of infectious diseases, Vol.225(10), pp.1694-1700
DOI: 10.1093/infdis/jiab619
PMID: 34932114
PMCID: PMC9113447
NLM abbreviation: J Infect Dis
ISSN: 0022-1899
eISSN: 1537-6613
Publisher: Oxford Univ Press
Number of pages: 7
Grant note: UL1 TR002243 / National Center for Advancing Translational Sciences; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) 75D30121F00002 / US Centers for Disease Control and Prevention; United States Department of Health & Human Services; Centers for Disease Control & Prevention - USA 1K23AI137321 / National Institute of Allergy and Infectious Diseases, National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID)
Language: English
Date published: 12/21/2021
Academic Unit: Epidemiology; Emergency Medicine; Pharmacy Practice and Science; Anesthesia; Injury Prevention Research Center
Record Identifier: 9984295958702771

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