Journal article
Effectiveness of the Dexamethasone Implant in Lieu of Oral Corticosteroids in Intermediate and Posterior Uveitis Requiring Immunosuppression
Ocular immunology and inflammation, Vol.30(3), pp.741-749
04/03/2022
DOI: 10.1080/09273948.2020.1826534
PMID: 33021854
Abstract
To evaluate dexamethasone intravitreal implant effectiveness in lieu of high-dose oral prednisone for short-term treatment of noninfectious intermediate and posterior uveitis in patients requiring immunosuppression.
This is a proof-of-concept, open-label, non-comparative clinical trial with 12-month follow-up. The primary outcome was uveitis control without additional prednisone at 6 and 12 months. Secondary outcomes were need for multiple implants or additional prednisone, and safety data.
20 patients (28 eyes) were enrolled- 16 eyes had control by 6 months; 20 by 12 months. No patients required high-dose prednisone. 6 patients enrolled on prednisone: 2 stopped; 4 tapered to 7.5 mg daily or less by 12 months. 16 eyes required multiple implants; five required cataract surgery; 12 required drops to control IOP; 2 underwent glaucoma surgery.
The dexamethasone implant was effective in lieu of high-dose prednisone although the majority required multiple implants. All patients decreased or discontinued prednisone during follow-up.
Details
- Title: Subtitle
- Effectiveness of the Dexamethasone Implant in Lieu of Oral Corticosteroids in Intermediate and Posterior Uveitis Requiring Immunosuppression
- Creators
- Meghan K. Berkenstock - Johns Hopkins MedicineTahreem A. Mir - Johns Hopkins MedicineIrfan R. Khan - Johns Hopkins MedicineBryn M. Burkholder - Johns Hopkins MedicineBenjamin C. Chaon - Johns Hopkins UniversityAmde Selassie Shifera - Johns Hopkins MedicineJennifer E. Thorne - Johns Hopkins University
- Resource Type
- Journal article
- Publication Details
- Ocular immunology and inflammation, Vol.30(3), pp.741-749
- Publisher
- Taylor & Francis
- DOI
- 10.1080/09273948.2020.1826534
- PMID
- 33021854
- ISSN
- 0927-3948
- eISSN
- 1744-5078
- Number of pages
- 9
- Language
- English
- Date published
- 04/03/2022
- Academic Unit
- Ophthalmology and Visual Sciences
- Record Identifier
- 9984756265802771
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