Journal article
Effects of Adenosine and 2-Chloroadenosine on Cerebral Collateral Vessels
Journal of cerebral blood flow and metabolism, Vol.15(6), pp.1075-1081
11/1995
DOI: 10.1038/jcbfm.1995.134
PMID: 7593340
Abstract
Adenosine is a potent cerebral vasodilator. We tested the hypothesis that dilatation of collateral vessels in cerebrum, in response to topical adenosine and 2-chloroadenosine (2-CAD), would increase blood flow to collateral-dependent cerebrum. In dogs anesthetized with halothane, a branch of the middle cerebral artery (MCA) was occluded proximally and cannulated distally. The collateral-dependent area at risk for infarction was perfused from a reservoir with microsphere-free blood, and blood flow to normal cerebrum and to cerebrum dependent on collateral flow was measured with radioactive microspheres injected into the left ventricle through a femoral artery catheter. Perfusion through the cannulated MCA branch was stopped, and flow to normal and collateral-dependent cerebrum was measured after adenosine (10−2 M) or 2-CAD (10−4 M) was added to the superfusate over the cerebrum. In normal cerebrum, topical application of adenosine increased flow to outer but not inner layers. Topical application of adenosine had little effect on flow to collateral-dependent tissue. In normal cerebrum, 2-CAD increased flow to outer layers, whereas flow to inner layers tended to increase. During 2-CAD, flow to outer cortical layers of collateral-dependent cerebrum increased from 140 ± 20 ml/100 g/min (mean ± SD) to 231 ± 68, whereas flow to the inner collateral-dependent tissue did not change. The findings indicate that, after occlusion of a cerebral artery, topical 2-CAD increases blood flow to outer layers of collateral-dependent and normal cerebrum. The findings suggest also that, after arterial occlusion, collateral circulation to cerebrum has dilator reserve, and flow to tissues that are dependent on collaterals may be augmented.
Details
- Title: Subtitle
- Effects of Adenosine and 2-Chloroadenosine on Cerebral Collateral Vessels
- Creators
- Michael G Muhonen - Department of Surgery (Division of Neurosurgery), Iowa City, Iowa, U.S.AChristopher M Loftus - Department of Surgery (Division of Neurosurgery), Iowa City, Iowa, U.S.ADonald D Heistad - Department of Surgery (Division of Neurosurgery), Iowa City, Iowa, U.S.A
- Resource Type
- Journal article
- Publication Details
- Journal of cerebral blood flow and metabolism, Vol.15(6), pp.1075-1081
- Publisher
- SAGE Publications; London, England
- DOI
- 10.1038/jcbfm.1995.134
- PMID
- 7593340
- ISSN
- 0271-678X
- eISSN
- 1559-7016
- Language
- English
- Date published
- 11/1995
- Academic Unit
- Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984040435602771
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