Journal article
Effects of Bile Duct Ligation and Captopril on Salt Appetite and Renin–Aldosterone Axis in Rats
Physiology & behavior, Vol.66(3), pp.419-425
1999
DOI: 10.1016/S0031-9384(98)00295-9
PMID: 10357430
Abstract
A ligation of the common bile duct (BDL) produces cholestasis and hypotension and increases the daily ingestion of sodium chloride solutions in rats. Low-dose captopril (CAP) treatment also modifies the ingestion of water and sodium in naive rats, and may do so in cholestatic rats. This study examined whether the elevated ingestion of saline by Long–Evans rats after BDL is associated with increased plasma renin activity (PRA), and whether treatment with a low dose of the angiotensin converting-enzyme inhibitor CAP further exacerbates fluid intake and PRA after BDL. In these experiments water and 0.3 M saline intake and PRA and plasma aldosterone (PA) were measured in naive and CAP-treated BDL and sham-ligated rats. We found that BDL elevated rats’ daily saline intake 2 weeks after the ligation procedure but had no effect on PRA. CAP (0.1 mg/mL) placed in the drinking water of some BDL rats further increased saline intake. Both PA and hematocrits tended to be reduced in BDL rats, whereas PRA was elevated in both BDL and sham-ligated rats receiving CAP in the drinking water or by gavage (0.1 mg/mL in 10 mL/kg). The data suggest that the ingestion of saline by rats can be modified by BDL and CAP administration, but that exaggerated saline intake in BDL rats is not associated with excessive renin secretion.
Details
- Title: Subtitle
- Effects of Bile Duct Ligation and Captopril on Salt Appetite and Renin–Aldosterone Axis in Rats
- Creators
- Jeannine R Lane - Department of Psychology, Box 351525, University of Washington, Seattle, WA 98195, USAElizabeth M Starbuck - Department of Psychology, Box 351525, University of Washington, Seattle, WA 98195, USAAlan Kim Johnson - Departments of Psychology and Pharmacology and the Cardiovascular Center, University of Iowa, Iowa City, IA 52242 USADouglas A Fitts - Department of Psychology, Box 351525, University of Washington, Seattle, WA 98195, USA
- Resource Type
- Journal article
- Publication Details
- Physiology & behavior, Vol.66(3), pp.419-425
- DOI
- 10.1016/S0031-9384(98)00295-9
- PMID
- 10357430
- NLM abbreviation
- Physiol Behav
- ISSN
- 0031-9384
- eISSN
- 1873-507X
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 1999
- Academic Unit
- Psychological and Brain Sciences; Neuroscience and Pharmacology; Health, Sport, and Human Physiology
- Record Identifier
- 9984213269402771
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