Journal article
Effects of Cholinergic Nerves on Cerebral Blood Flow in Cats
Circulation research, Vol.48(1), pp.62-69
01/1981
DOI: 10.1161/01.RES.48.1.62
PMID: 6777068
Abstract
We studied the effects of parasympathetic nerves on cerebral blood flow (CBF). The greater superficial petrosal nerve, which apparently supplies cholinergic fibers to cerebral vessels and the lacrimal gland, was sectioned on one side at the internal auditory meatus in anesthetized cats. CBF was measured with 15-/un microspheres. Section of the petrosal nerve did not alter resting CBF. In addition, electrical stimulation of the distal cut end of the petrosal nerve had no effect on total CBF. In one area of the brain, the caudate nucleus, stimulation increased blood flow from 29 ± 2 to 38 ± 2 (mean ± SE) ml/min per 100 g. Lacrimal gland blood flow increased from 42 ± 7 to 198 ± 32 ml/min per 100 g during petrosal stimulation, which indicates that the stimulus was potent. In the same experiments, CBF increased 3- to 4-fold during hypercapnia; thus, cerebral vessels were responsive to another dilator stimulus. In other experiments, petrosal nerve section did not alter the response of cerebral vessels to hypercapnia (Pco2 > 50 mm Hg) or hypoxia (Po2 < 34 mm Hg). We conclude(1) there is little or no resting vasodilator tone provided to cerebral vessels by the petrosal nerve; (2) petrosal nerve stimulation has a major effect on blood flow to the lacrimal gland but does not increase CBF; and (3) petrosal nerve section has little effect on the response of cerebral vessels to hypercapnia or hypoxia. Circ Res 4862-69, 1981
Details
- Title: Subtitle
- Effects of Cholinergic Nerves on Cerebral Blood Flow in Cats
- Creators
- DAVID BUSIJA - From the Cardiovascular Division, Department of Internal Medicine and the Cardiovascular Center, University of Iowa College of Medicine and Veterans Administration Hospital, Iowa City, IowaDONALD HEISTAD
- Resource Type
- Journal article
- Publication Details
- Circulation research, Vol.48(1), pp.62-69
- Publisher
- American Heart Association, Inc
- DOI
- 10.1161/01.RES.48.1.62
- PMID
- 6777068
- ISSN
- 0009-7330
- eISSN
- 1524-4571
- Language
- English
- Date published
- 01/1981
- Academic Unit
- Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984040444302771
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