Journal article
Effects of Conjugated Equine Estrogens on Cognition and Affect in Postmenopausal Women with Prior Hysterectomy
The journal of clinical endocrinology and metabolism, Vol.94(11), pp.4152-4161
11/01/2009
DOI: 10.1210/jc.2009-1340
PMCID: PMC2775644
PMID: 19850684
Abstract
Context: Different menopausal hormone therapies may have varied effects on specific cognitive functions. We previously reported that conjugated equine estrogens (CEE) with medroxyprogesterone acetate had a negative impact on verbal memory but tended to impact figural memory positively over time in older postmenopausal women.
Objective: The objective of the study was to determine the effects of unopposed CEE on changes in domain-specific cognitive function and affect in older postmenopausal women with prior hysterectomy.
Design: This was a randomized, double blind, placebo-controlled clinical trial.
Setting: The study was conducted at 14 of 40 Women's Health Initiative (WHI) clinical centers.
Participants: Participants were 886 postmenopausal women with prior hysterectomy, aged 65 yr and older (mean 74 yr), free of probable dementia, and enrolled in the WHI and WHI Memory Study (WHIMS) CEE-Alone trial for a mean of 3 yr and followed up for a mean of 2.70 yr.
Intervention: Intervention was 0.625 mg of CEE daily or placebo.
Main Outcome Measures: Annual rates of change in specific cognitive functions and affect, adjusted for time since randomization, were measured.
Results: Compared with placebo, unopposed CEE was associated with lower spatial rotational ability (P < 0.01) at initial assessment (after 3 yr of treatment), a difference that diminished over 2.7 yr of continued treatment. CEE did not significantly influence change in other cognitive functions and affect.
Conclusions: CEE did not improve cognitive functioning in postmenopausal women with prior hysterectomy. CEE was associated with lower spatial rotational performance after an average of 3 yr of treatment. Overall, CEE does not appear to have enduring effects on rates of domain-specific cognitive change in older postmenopausal women. (J Clin Endocrinol Metab 94: 4152-4161, 2009)
Details
- Title: Subtitle
- Effects of Conjugated Equine Estrogens on Cognition and Affect in Postmenopausal Women with Prior Hysterectomy
- Creators
- Susan M. Resnick - National Institute on AgingMark A. Espeland - Wake Forest UniversityYang An - Medstar Res Inst, Hyattsville, MD 20785 USAPauline M. Maki - National Institute on AgingLaura H. Coker - Wake Forest UniversityRebecca Jackson - The Ohio State UniversityMarcia L. Stefanick - Stanford UniversityRobert Wallace - University of IowaStephen R. Rapp - Wake Forest UniversityWomen’s Health Initiative Study of Cognitive Aging Investigators
- Resource Type
- Journal article
- Publication Details
- The journal of clinical endocrinology and metabolism, Vol.94(11), pp.4152-4161
- DOI
- 10.1210/jc.2009-1340
- PMID
- 19850684
- PMCID
- PMC2775644
- NLM abbreviation
- J Clin Endocrinol Metab
- ISSN
- 0021-972X
- eISSN
- 1945-7197
- Publisher
- Endocrine Soc
- Number of pages
- 10
- Grant note
- N01AG092115 / NATIONAL INSTITUTE ON AGING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) N01-AG-9-2115 / National Institute on Aging; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) Intramural Research Program of the National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA N01WH22110; 24152; 32100-2; 32105-6; 32108-9; 32111-13; 32115; 32118-32119; 32122; 42107-26; 42129-32; 44221 / U. S. Department of Health and Human Services Wyeth Pharmaceuticals; Wyeth N01WH022110 / WOMEN'S HEALTH INITIATIVE - OFFICE OF THE DIRECTOR NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA National Heart, Lung, and Blood Institute, National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI)
- Language
- English
- Date published
- 11/01/2009
- Academic Unit
- Epidemiology; Injury Prevention Research Center; Internal Medicine
- Record Identifier
- 9984364414302771
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