Journal article
Effects of Coronavirus Disease 2019 on Solid Organ Transplantation
Transplantation proceedings, Vol.52(9), pp.2642-2653
11/01/2020
DOI: 10.1016/j.transproceed.2020.09.006
PMCID: PMC7491991
PMID: 33127076
Abstract
Background. As the novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has emerged as a viral pandemic, data on the clinical characteristics and outcomes of patients with SARS-CoV-2 infection undergoing solid organ transplant are emerging. The objective of this systematic review was to assess currently published literature relating to the management, clinical course, and outcome of SARS-CoV-2 infection in liver, kidney, and heart solid organ transplant recipients.
Methods. We conducted a systematic review to assess currently published literature relating to the management, clinical course, and outcome of SARS-CoV-2 infection in liver, kidney, and heart solid organ transplant recipients. Articles published through June 2020 were searched in the MEDLINE, Clinical Trials.gov, and PubMed databases. We identified 49 eligible studies comprising a total of 403 solid organ transplant recipients.
Results. Older age, male sex, and preexisting comorbidities, including hypertension and/ or diabetes, were the most common prevailing characteristics among the solid organ transplant recipients. Clinical presentation ranged from mild to severe disease, including multiorgan failure and death. We found an overall mortality rate of 21%.
Conclusion. Our analysis suggests no increase in overall mortality or worse outcome in solid organ transplant recipients receiving immunosuppressive therapy compared with mortality in the general surgical population with SARS-CoV-2. Our findings suggest that transplant surgery and its immunosuppressive effects should not be a deterrent to proper surgical care for patients in the SARS-CoV-2 era.
Details
- Title: Subtitle
- Effects of Coronavirus Disease 2019 on Solid Organ Transplantation
- Creators
- Hassan Aziz - University of Southern CaliforniaNassim Lashkari - University of Southern CaliforniaYoung Chul Yoon - The Catholic University of Korea Incheon St. Mary's HospitalJim Kim - University of Southern CaliforniaLinda S. Sher - University of Southern CaliforniaYuri Genyk - University of Southern CaliforniaYong K. Kwon - University of Southern California
- Resource Type
- Journal article
- Publication Details
- Transplantation proceedings, Vol.52(9), pp.2642-2653
- DOI
- 10.1016/j.transproceed.2020.09.006
- PMID
- 33127076
- PMCID
- PMC7491991
- NLM abbreviation
- Transplant Proc
- ISSN
- 0041-1345
- eISSN
- 1873-2623
- Publisher
- Elsevier
- Number of pages
- 12
- Language
- English
- Date published
- 11/01/2020
- Academic Unit
- Surgery
- Record Identifier
- 9984701647202771
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