Journal article
Effects of Endothelin Receptor Inhibition on Cerebral Arterioles in Hypertensive Rats
Hypertension (Dallas, Tex. 1979), Vol.27(3), pp.794-798
03/1996
DOI: 10.1161/01.HYP.27.3.794
PMID: 8613242
Abstract
The purpose of this study was to examine the effects of endothelin receptor inhibition on cerebral arterioles in stroke-prone spontaneously hypertensive rats (SHRSP). Structure and mechanics of cerebral arterioles were examined in untreated Wistar-Kyoto rats (WKY) and SHRSP that were either untreated or treated for 3 months with bosentan, an inhibitor of endothelin receptors (100 mg/kg per day). We measured pressure, external diameter, and cross-sectional area of the vessel wall (histologically) in maximally dilated (EDTA) arterioles on the cerebrum. Bosentan reduced but did not normalize arteriolar mean pressure (103 plus/minus 3 and 81 plus/minus 5 mm Hg in untreated and treated SHRSP versus 51 plus/minus 4 mm Hg in WKY, P < .05; mean plus/minus SEM) and pulse pressure (40 plus/minus 2 and 33 plus/minus 2 mm Hg in untreated and treated SHRSP versus 25 plus/minus 3 mm Hg in WKY, P < .05) in SHRSP. Cross-sectional area of the vessel wall (CSA) was increased in untreated SHRSP (1627 plus/minus 173 micro meter), and CSA in treated SHRSP (1287 plus/minus 78 micro meter) was similar to that in WKY (1299 plus/minus 65 micro meter). Bosentan had no effect on reductions in external diameter (remodeling) of cerebral arterioles (104 plus/minus 7 and 96 plus/minus 4 micro meter in untreated and treated SHRSP compared with 126 plus/minus 7 micro meter in WKY, P < .05). Stress-strain curves indicate that bosentan had no significant effect on distensibility of arterioles on the cerebrum in SHRSP. The results suggest that endothelin-1 may contribute to the development of hypertrophy, but not remodeling or changes in distensibility, of cerebral arterioles in SHRSP. (Hypertension. 1996;27[part 2]:794-798.)
Details
- Title: Subtitle
- Effects of Endothelin Receptor Inhibition on Cerebral Arterioles in Hypertensive Rats
- Creators
- Jean-Marc Chillon - From the University of Iowa College of Medicine, Departments of Pathology (J-M.C. and G.L.B.), Internal Medicine and Pharmacology (D.D.H.), and the Cardiovascular Center, Iowa City, Ia. Reprint requests to Jean-Marc Chillon, PhD, Department of Pathology, 146 Medical Laboratories, University of Iowa College of Medicine, Iowa City, IA 52242Donald D HeistadGary L Baumbach
- Resource Type
- Journal article
- Publication Details
- Hypertension (Dallas, Tex. 1979), Vol.27(3), pp.794-798
- Publisher
- American Heart Association, Inc
- DOI
- 10.1161/01.HYP.27.3.794
- PMID
- 8613242
- ISSN
- 0194-911X
- eISSN
- 1524-4563
- Language
- English
- Date published
- 03/1996
- Academic Unit
- Pathology; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984040598802771
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