Journal article
Effects of Equimolar Doses of L-Methionine, D-Methionine and L-Methionine-dl-Sulfoxide on Plasma and Urinary Amino Acid Levels in Normal Adult Humans
The Journal of nutrition, Vol.116(7), pp.1185-1192
07/01/1986
DOI: 10.1093/jn/116.7.1185
PMID: 3746457
Abstract
Plasma and urinary amino acid levels were measured in four normal adult subjects administered equimolar quantities (0.0605 mmol/kg body wt) of L-methionine, D-methionine and L-methionine-dl-sulfoxide in a randomized cross-over design. Plasma total methionine concentrations increased significantly (P < 0.05) over base line (3.7 ± 1.2 μmol/dl; mean ± SD) after loading with each compound. Mean peak plasma methionine levels were 9.8 ± 1.1, 14.4 ± 2.3 and 5.2 ± 1.0 μmol/dl after loading with L-methionine, D-methionine and L-methionine sulfoxide, respectively. D-Methionine accounted for the increased plasma levels seen after D-methionine loading. None of the three compounds affected plasma cystine, cysteine or taurine concentrations. Plasma methionine sulfoxide concentrations were not affected by loading with D- or L-methionine but increased significantly after ingestion of L-methionine sulfoxide. Urinary methionine excretion was 20 times higher after ingestion of D-methionine than after ingestion of L-methionine or L-methionine sulfoxide, with the increase due to D-methionine excretion. Urinary excretion of methionine sulfoxide and its N-acetyl derivatives was not significantly higher after loading with methionine sulfoxide. The data indicate that adult humans do not utilize D-methionine efficiently as a methionine source but probably do utilize L-methionine-dl-sulfoxide.
Details
- Title: Subtitle
- Effects of Equimolar Doses of L-Methionine, D-Methionine and L-Methionine-dl-Sulfoxide on Plasma and Urinary Amino Acid Levels in Normal Adult Humans
- Creators
- Lewis D. Stegink - University of IowaEdward F. Bell - University of IowaL. J. Filer - University of IowaE. E. Ziegler - University of IowaDean W. Andersen - University of IowaFrances H. Seligson - Procter & Gamble
- Resource Type
- Journal article
- Publication Details
- The Journal of nutrition, Vol.116(7), pp.1185-1192
- DOI
- 10.1093/jn/116.7.1185
- PMID
- 3746457
- ISSN
- 0022-3166
- eISSN
- 1541-6100
- Language
- English
- Date published
- 07/01/1986
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology
- Record Identifier
- 9984353936902771
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