Journal article
Effects of FKBP-12 ligands following tibial nerve injury in rats
Journal of reconstructive microsurgery, Vol.16(8), pp.613-620
11/01/2000
DOI: 10.1055/s-2000-9379
PMID: 11127284
Abstract
-The neuroregenerative properties of FK506, an FKBP-12 ligand that inhibits calcineurin, and V-10,367, an FKBP-12 ligand that does not inhibit calcineurin, were evaluated in crush and transection models. Rats were randomly assigned to one of seven groups, including untreated controls and FK506- or V-10,367-treated experimental groups. Following crush or transection nerve injury, animals were assessed with walking tracks, and histomorphometry. FK506-treated animals demonstrated significant functional recovery 11 days following crush and 18 days following transection injury. In untreated and V-10,367 treated animals, nerves recovered 13 days following crush injury, but did not improve significantly prior to sacrifice at 28 days in animals sustaining a transection injury. No statistically significant differences in histomorphometric parameters were identified between any of the groups. The study confirms that FK506 accelerates recovery from tibial nerve injury.
Details
- Title: Subtitle
- Effects of FKBP-12 ligands following tibial nerve injury in rats
- Creators
- Devra B Becker - Washington University in St. LouisJohn N Jensen - Washington University in St. LouisTerence M Myckatyn - Washington University in St. LouisVaishali B Doolabh - Washington University in St. LouisDaniel A Hunter - Washington University in St. LouisSusan E Mackinnon - Washington University in St. Louis
- Resource Type
- Journal article
- Publication Details
- Journal of reconstructive microsurgery, Vol.16(8), pp.613-620
- Publisher
- Thieme
- DOI
- 10.1055/s-2000-9379
- PMID
- 11127284
- ISSN
- 0743-684X
- eISSN
- 1098-8947
- Number of pages
- 8
- Language
- English
- Date published
- 11/01/2000
- Academic Unit
- Surgery
- Record Identifier
- 9984701649002771
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