Journal article
Effects of Intermittent Pressure Loading on the Development of Ventricular Hypertrophy in the Cat
Circulation research, Vol.40(5), pp.484-488
05/1977
DOI: 10.1161/01.RES.40.5.484
PMID: 140026
Abstract
Although the effects of persistent pressure loading on the development of ventricular hypertrophy have been studied extensively, the effects of intermittent pressure loading have not been examined. To study the effects of intermittent pressure loading we subjected the right ventricle of cats to intermittent pulmonary artery constriction over a 2-week period. Two intermittent pressure loading schedules were employed. The first consisted of a right ventricular systolic pressure of 60 mm Hg for 3.5 days and normal right ventricular pressure for 3.5 days; and the second consisted of a right ventricular systolic pressure of 60 mm Hg for 2.3 days and normal right ventricular pressure for 4.7 days. The intermittent pressure-loaded cats were compared with normal unoperated controls, sham-operated controls, and cats with a persistent right ventricular pressure load for either 1-week or 1- to 2-month duration. The data indicate that intermittent pressure loading caused significant right ventricular hypertrophy. Since significant residual ventricular hypertrophy was present in both intermittent pressure loading groups, regression of ventricular hypertrophy involves a slower process than the progression of hypertrophy.
Details
- Title: Subtitle
- Effects of Intermittent Pressure Loading on the Development of Ventricular Hypertrophy in the Cat
- Creators
- MELVIN MARCUS - Cardiovascular Center and the Cardiovascular Division, Department of Internal Medicine, University of Iowa and Veterans Administration Hospitals, Iowa City, IowaDWAIN ECKBERGJAMES BRAXMEIERFRANCOIS ABBOUD
- Resource Type
- Journal article
- Publication Details
- Circulation research, Vol.40(5), pp.484-488
- Publisher
- American Heart Association, Inc
- DOI
- 10.1161/01.RES.40.5.484
- PMID
- 140026
- ISSN
- 0009-7330
- eISSN
- 1524-4571
- Language
- English
- Date published
- 05/1977
- Academic Unit
- Molecular Physiology and Biophysics; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9984025588002771
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