Journal article
Effects of Intermittently Scanned Continuous Glucose Monitoring in Adult Type 1 Diabetes Patients with Suboptimal Glycemic Control: A Multi-Center Randomized Controlled Trial
Diabetes/metabolism research and reviews, Vol.39(4), e3614
05/2023
DOI: 10.1002/dmrr.3614
PMID: 36670050
Abstract
To investigate whether intermittently scanned continuous glucose monitoring without alarms (isCGM) improves glycemic control over capillary blood glucose monitoring (BGM) among adult type 1 diabetes mellitus (T1DM) patients with suboptimal control.
Adults with T1DM and HbA1c between 7% and 10% were 1:1 randomized to use isCGM or BGM for 24 weeks. The primary outcome was the change in HbA1c after intervention. The secondary outcomes were the change in sensor-derived metrics.
A total of 104 adults with T1DM (34.2±12.2 years; M/F, 38/66) were randomized to isCGM group (n=54) and BGM group (n=50). After 24 weeks, HbA1c significantly decreased in isCGM group (8.1±0.7% to 7.5±1.0 %) and BGM group (8.0±0.8% to 7.7±1.0%), with between-group difference as 0.3% (95% CI, 0.0% to 0.6%; P=0.04). Percentage of HbA1c reduction over 1.0% and 1.5% was significantly higher in isCGM group, with adjusted odd ratios of 2.5 (95% CI: 1.1 to 5.5; P=0.03) and 3.2 (95% CI: 1.1 to 9.0; P=0.03). Mean time-in-range 70-180 mg/dL (TIR) in isCGM group significantly increased (from 58.5±13.0% to 63.0±12.6%), while mean TIR was similar in BGM group (from 58.0±14.6% to 57.5±14.5%). Time spent in hyperglycemia reduced more in isCGM group and time spent in hypoglycemia did not change significantly in both groups.
Among adult T1DM patients with suboptimal glycemic control, compared with BGM, isCGM use resulted in a statistically significant improvement in glycemic control after 24-week intervention. This article is protected by copyright. All rights reserved.
Details
- Title: Subtitle
- Effects of Intermittently Scanned Continuous Glucose Monitoring in Adult Type 1 Diabetes Patients with Suboptimal Glycemic Control: A Multi-Center Randomized Controlled Trial
- Creators
- Jinhua Yan - Third Affiliated Hospital of Sun Yat-sen UniversityYongwen Zhou - University of Science and Technology of ChinaXueying Zheng - University of Science and Technology of ChinaMao Zheng - University of Science and Technology of ChinaJing Lu - Nanjing UniversitySihui Luo - University of Science and Technology of ChinaDaizhi Yang - Third Affiliated Hospital of Sun Yat-sen UniversityHongrong Deng - Third Affiliated Hospital of Sun Yat-sen UniversityWen Xu - Third Affiliated Hospital of Sun Yat-sen UniversityYan Bi - Nanjing UniversityWei Bao - University of Science and Technology of ChinaJianping Weng - University of Science and Technology of China
- Resource Type
- Journal article
- Publication Details
- Diabetes/metabolism research and reviews, Vol.39(4), e3614
- DOI
- 10.1002/dmrr.3614
- PMID
- 36670050
- NLM abbreviation
- Diabetes Metab Res Rev
- ISSN
- 1520-7552
- eISSN
- 1520-7560
- Grant note
- DOI: 10.13039/501100001809, name: National Natural Science Foundation of China; DOI: 10.13039/501100013104, name: Shanghai Health and Medical Development Foundation; DOI: 10.13039/501100012166, name: National Key Research and Development Program of China
- Language
- English
- Electronic publication date
- 01/20/2023
- Date published
- 05/2023
- Academic Unit
- Epidemiology
- Record Identifier
- 9984364362602771
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