Journal article
Effects of Liposome-Entrapped Doxorubicin on Liver Metastases of Mouse Colon Carcinomas 26 and 38
JNCI : Journal of the National Cancer Institute, Vol.78(4), pp.707-713
04/1987
DOI: 10.1093/jnci/78.4.707
PMID: 3470546
Abstract
The effects of doxorubicin (DOX) and DOX entrapped in standardized liposomes [mean diameter, 0.15 μm; (DOX-Lip)] on the survival of mice bearing liver metastases of mouse colon carcinoma CT38LD (C57BL/6J mice) or CT26 (BALB/c mice) were investigated. In vitro cultured CT38LD cells were more sensitive to DOX than CT26. In vivo DOX and DOX-Lip, administered iv 10 mg/kg weekly to a maximum of five injections, increased the life-spans of mice bearing CT38LD liver metastases 32% (P<.05) and 64% (P<.05), respectively. DOX-Lip was more effective than DOX in prolonging survival (P<.05). Free DOX did not significantly increase the life-spans of mice bearing CT26 liver metastases (P>.5), whereas DOX-Lip increased the life-spans 35% (P<.05). The results suggest that liposomal delivery of agents to the liver can enhance therapeutic activity and could be used as an arm of protocols for adjuvant therapy of liver metastases.
Details
- Title: Subtitle
- Effects of Liposome-Entrapped Doxorubicin on Liver Metastases of Mouse Colon Carcinomas 26 and 38
- Creators
- Eric G. MayhewMartin H. GoldrosenJan VaageYoucef M. Rustum
- Resource Type
- Journal article
- Publication Details
- JNCI : Journal of the National Cancer Institute, Vol.78(4), pp.707-713
- Publisher
- Oxford University Press
- DOI
- 10.1093/jnci/78.4.707
- PMID
- 3470546
- ISSN
- 0027-8874
- eISSN
- 1460-2105
- Language
- English
- Date published
- 04/1987
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984359686702771
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