Journal article
Effects of Long-Term Therapy with Oral Piroximone on Resting Hemodynamics, Peak Aerobic Capacity, and the Anaerobic Threshold in Patients with Heart Failure
Journal of cardiovascular pharmacology, Vol.10(5), pp.580-588
11/1987
DOI: 10.1097/00005344-198711000-00014
PMID: 2447409
Abstract
SUMMARYPiroximone (MDL 19205), a new imidazole derivative with positive inotropic and vasodilating properties, was administered to 10 patients with congestive heart failure. After acute intravenous (0.90 ± 0.12 mg/kg, mean ± SEM) and oral (1.41 ± 0.18 mg/kg) administration, cardiac index and stroke volume index increased and were accompanied by a decline in systemic vascular resistance, pulmonary capillary wedge pressure, and right atrial pressure. Mean arterial pressure was unchanged, but heart rate increased modestly after intravenous piroximone. An increase in premature ventricular contractions was documented in four patients after drug administration. Seven of the 10 patients completed 12 weeks of therapy with piroximoneone patient withdrew after 8 weeks because of deterioration in clinical status; one developed severe ventricular arrhythmias and died after 5 days of treatmentand a drug-induced hepatitis was documented in one subject at 4 weeks. No significant improvement in oxygen uptake at peak exercise and the anaerobic threshold was observed after long-term treatment (assessed at 6 and 12 weeks). Hemodynamic responsiveness to piroximone was sustained in five patients who underwent repeat evaluation at 12 weeks. Thus, long-term treatment with piroximone was not associated with an improvement in maximal and submaximal exercise capacity in patients with congestive heart failure. Serious adverse effects were observed with the administration of this drug.
Details
- Title: Subtitle
- Effects of Long-Term Therapy with Oral Piroximone on Resting Hemodynamics, Peak Aerobic Capacity, and the Anaerobic Threshold in Patients with Heart Failure
- Creators
- John Nemanich - Section of Cardiology and Committee on Clinical Pharmacology, Departments of Medicine and Pharmacological and Physiological Sciences, University of Chicago, Chicago, Illinois, U.S.AAlan ShurmanJames RossenCynthia KremserFetima DavisSol Rajfer
- Resource Type
- Journal article
- Publication Details
- Journal of cardiovascular pharmacology, Vol.10(5), pp.580-588
- Publisher
- Lippincott-Raven Publishers
- DOI
- 10.1097/00005344-198711000-00014
- PMID
- 2447409
- ISSN
- 0160-2446
- eISSN
- 1533-4023
- Language
- English
- Date published
- 11/1987
- Academic Unit
- Neurology; Cardiovascular Medicine; Neurosurgery; Internal Medicine
- Record Identifier
- 9984020871802771
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