Journal article
Effects of Nitroglycerin on Regional Myocardial Blood Flow in Coronary Artery Disease
The Journal of clinical investigation, Vol.50(8), pp.1578-1584
08/01/1971
DOI: 10.1172/jci106645
PMCID: PMC442056
PMID: 4999635
Abstract
Regional myocardial blood flow before and after sublingual nitroglycerin was measured in 10 patients with coronary artery disease. During thoracotomy,
133
Xe was injected directly into the subepicardium in diseased regions of the anterior left ventricular wall, and washout rates were recorded with a scintillation counter. All disappearance curves were closely approximated by two exponential decays analyzed as two parallel flow systems by the compartmental method. The appearance of a double exponential decay pattern in diseased regions suggests that the slow phase was associated with collateral blood flow, although nonhomogeneous myocardium-to-blood partition coefficients for xenon cannot be excluded. Nitroglycerin increased the rapid phase flow in 9 of 10 patients and the slow flow in 7 of 10 patients. Average flow increased in 9 of the 10 patients (
P
< 0.01). Mean rapid phase flow in the control state was 110 ml/100 g per min and after nitroglycerin increased to 132 ml/100 g per min (
P
< 0.01); slow phase flow increased from 12 ml/100 g per min to 15 ml/100 g per min (
P
< 0.05). It is concluded that, under these conditions, nitroglycerin improves perfusion in regions of diseased myocardium in patients with coronary artery disease.
Details
- Title: Subtitle
- Effects of Nitroglycerin on Regional Myocardial Blood Flow in Coronary Artery Disease
- Creators
- Lawrence D. Horwitz - Brigham and Women's HospitalRichard Gorlin - Harvard UniversityWarren J. Taylor - Harvard UniversityHarvey G. Kemp - Brigham and Women's Hospital
- Resource Type
- Journal article
- Publication Details
- The Journal of clinical investigation, Vol.50(8), pp.1578-1584
- DOI
- 10.1172/jci106645
- PMID
- 4999635
- PMCID
- PMC442056
- ISSN
- 0021-9738
- eISSN
- 1558-8238
- Language
- English
- Date published
- 08/01/1971
- Academic Unit
- Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984656531102771
Metrics
4 Record Views