Journal article
Effects of Nucleus on Leukocyte Recovery
Annals of biomedical engineering, Vol.27(5), pp.648-655
09/1999
DOI: 10.1114/1.214
PMID: 10548334
Abstract
The rheological properties of a leukocyte significantly affect its biological and mechanical characteristics. To date, existing physical models of leukocyte are not capable of quantitatively explaining the wide range of deformation and recovery behaviors observed in experiment. However, a compound drop model has gained some success. In the present work, we investigate the effect of nucleus size and position, and the relative rheological properties of cytoplasm and nucleus, on cell recovery dynamics. Two nucleus sizes corresponding to that of neutrophil and lymphocyte are considered. Direct comparison between numerical simulations and experimental observation is made. Results indicate that the time scale ratio between the nucleus and cytoplasm plays an important role in cell recovery characteristics. Comparable time scales between the two cell components yield favorable agreement in recovery rates between numerical and experimental observations; disparate time scales, on the other hand, result in recovery behavior and cell shapes inconsistent with experiments. Furthermore, it is found that the nucleus eccentricity exhibits minimum influence on all major aspects of the cell recovery characteristics. The present work offers additional evidence in support of the compound cell model for predicting the rheological behavior of leukocytes. © 1999 Biomedical Engineering Society.
PAC99: 8717-d, 8719Tt
Details
- Title: Subtitle
- Effects of Nucleus on Leukocyte Recovery
- Creators
- Heng-Chuan Kan - Department of Aerospace Engineering, Mechanics and Engineering Science University of Florida Gainesville FLWei Shyy - Department of Aerospace Engineering, Mechanics and Engineering Science University of Florida Gainesville FLH Udaykumar - Department of Aerospace Engineering, Mechanics and Engineering Science University of Florida Gainesville FLPhilippe Vigneron - Department of Aerospace Engineering, Mechanics and Engineering Science University of Florida Gainesville FLRoger Tran-Son-Tay - Department of Aerospace Engineering, Mechanics and Engineering Science University of Florida Gainesville FL
- Resource Type
- Journal article
- Publication Details
- Annals of biomedical engineering, Vol.27(5), pp.648-655
- DOI
- 10.1114/1.214
- PMID
- 10548334
- NLM abbreviation
- Ann Biomed Eng
- ISSN
- 0090-6964
- eISSN
- 1573-9686
- Publisher
- Kluwer Academic Publishers-Plenum Publishers; New York
- Language
- English
- Date published
- 09/1999
- Academic Unit
- Injury Prevention Research Center; Mechanical Engineering
- Record Identifier
- 9984064248202771
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