Journal article
Effects of Phenytoin on Plasma High-Density Lipoprotein Cholesterol Levels in Men with Low Levels of High-Density Lipoprotein Cholesterol
Journal of clinical pharmacology, Vol.35(8), pp.767-775
Accepted in revised form March 30, 1995
08/1995
DOI: 10.1002/j.1552-4604.1995.tb04118.x
PMID: 8522632
Abstract
A low level of high-density lipoprotein cholesterol (HDL-C) is an important and common risk factor for coronary heart disease. Cross-sectional studies and uncontrolled clinical trials have suggested that phenytoin can significantly raise HDL-C levels. This study was undertaken to determine whether phenytoin can raise HDL-C levels in men with low levels of HDL-C. Ninety-two men currently receiving outpatient care at a Veterans Affairs medical center and with baseline HDL-C levels < or = 1.16 mmol/L (45 mg/dL) were recruited to participate in this randomized, placebo-controlled, double-blind clinical trial. Participants received a placebo or 100 mg, 200 mg, or 300 mg of phenytoin once daily for 14 weeks. Lipid levels were measured at baseline and at 6, 10, and 14 weeks. After 14 weeks of treatment, the 200-mg and 300-mg phenytoin groups together achieved a significant 10% increase in HDL-C levels compared with placebo after adjusting for differences in baseline HDL-C levels, age, and body mass index. Other lipid levels did not significantly change in the phenytoin groups compared with placebo. Average compliance was 98% or greater for each of the treatment groups. Eighteen participants dropped out of the study with similar numbers from each treatment group. Side effects were mild and mostly transient. Low doses of phenytoin are well tolerated and can effectively increase HDL-C levels in men with low levels of HDL-C.
Details
- Title: Subtitle
- Effects of Phenytoin on Plasma High-Density Lipoprotein Cholesterol Levels in Men with Low Levels of High-Density Lipoprotein Cholesterol
- Creators
- Chris Goerdt - Department of Medicine, University of Minnesota, MinneapolisMary Keith - Department of Medicine, University of Minnesota, MinneapolisHanna Bloomfield Rubins - Section of General Internal Medicine, Minneapolis Veterans Affairs Medical Center, University of Minnesota, Minneapolis
- Resource Type
- Journal article
- Publication Details
- Journal of clinical pharmacology, Vol.35(8), pp.767-775
- Edition
- Accepted in revised form March 30, 1995
- Publisher
- Blackwell Publishing Ltd
- DOI
- 10.1002/j.1552-4604.1995.tb04118.x
- PMID
- 8522632
- ISSN
- 0091-2700
- eISSN
- 1552-4604
- Number of pages
- 9
- Language
- English
- Date published
- 08/1995
- Academic Unit
- General Internal Medicine; Internal Medicine
- Record Identifier
- 9984094580402771
Metrics
12 Record Views