Effects of Whole Milk Supplementation on Gut Microbiota and Cardiometabolic Biomarkers in Subjects with and without Lactose Malabsorption

Xiaoqin Li; Jiawei Yin; Yalun Zhu; Xiaoqian Wang; Xiaoli Hu; Wei Bao; Yue Huang; Liangkai Chen; Sijing Chen; Wei Yang; Zhilei Shan; Liegang Liu

doi:10.3390/nu10101403

Back

Effects of Whole Milk Supplementation on Gut Microbiota and Cardiometabolic Biomarkers in Subjects with and without Lactose Malabsorption

Journal article

Open access

Peer reviewed

Effects of Whole Milk Supplementation on Gut Microbiota and Cardiometabolic Biomarkers in Subjects with and without Lactose Malabsorption

Xiaoqin Li, Jiawei Yin, Yalun Zhu, Xiaoqian Wang, Xiaoli Hu, Wei Bao, Yue Huang, Liangkai Chen, Sijing Chen, Wei Yang, …

Nutrients, Vol.10(10), 1403

10/02/2018

DOI: 10.3390/nu10101403

PMCID: PMC6213503

PMID: 30279333

Files and links (1)

url

https://doi.org/10.3390/nu10101403View

Published (Version of record) Open Access

Abstract

The aim of this study was to compare the impact of whole milk supplementation on gut microbiota and cardiometabolic biomarkers between lactose malabsorbers (LM) and absorbers (LA). We performed a pair-wise intervention study of 31 LM and 31 LA, 1:1 matched by age, sex, body mass index, and daily dairy intake. Subjects were required to add 250 mL/day whole milk for four weeks in their routine diet. At the beginning and the end of the intervention period, we collected data on gut microbiota and cardiometabolic biomarkers. Whole milk supplementation significantly increased Actinobacteria ( < 0.01), ( < 0.01), ( < 0.01), and ( = 0.04), and decreased ( = 0.04) in LM, but not LA. Microbial richness and diversity were not affected. The fecal levels of short-chain fatty acids (SCFAs) remained stable throughout the study. Body fat mass ( < 0.01) and body fat percentage ( < 0.01) reduced in both groups, but the changes did not differ between groups. No significant differences in other cardiometabolic markers were found between LM and LA. When compared with LA, whole milk supplementation could alter the intestinal microbiota composition in LM, without significant changes in fecal SCFAs and cardiometabolic biomarkers.

Lactose Intolerance - microbiology

Milk - chemistry

Humans

Male

Gastrointestinal Microbiome - physiology

Biomarkers - blood

Bifidobacterium - isolation & purification

Lactose Intolerance - blood

Young Adult

Feces - microbiology

Animals

Milk - metabolism

Adult

Female

Actinobacteria - isolation & purification

Diet - methods

Details

Title: Subtitle: Effects of Whole Milk Supplementation on Gut Microbiota and Cardiometabolic Biomarkers in Subjects with and without Lactose Malabsorption
Creators: Xiaoqin Li - Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. immary@163.com
Jiawei Yin - Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. m201575208@hust.edu.cn
Yalun Zhu - Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. 15926237664@163.com
Xiaoqian Wang - Huazhong University of Science and Technology
Xiaoli Hu - Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. M201675193@hust.edu.cn
Wei Bao - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA 52242, USA. wei-bao@uiowa.edu
Yue Huang - Huazhong University of Science and Technology
Liangkai Chen - Huazhong University of Science and Technology
Sijing Chen - Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. sijingchen19@sina.com
Wei Yang - Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. yw8278@hotmail.com
Zhilei Shan - Departments of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. zshan@hsph.harvard.edu
Liegang Liu - Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. lgliu@mails.tjmu.edu.cn
Resource Type: Journal article
Publication Details: Nutrients, Vol.10(10), 1403
DOI: 10.3390/nu10101403
PMID: 30279333
PMCID: PMC6213503
NLM abbreviation: Nutrients
ISSN: 2072-6643
eISSN: 2072-6643
Publisher: Switzerland
Grant note: CNS-2015 / Chinese Nutrition Society Research Fund 2017YFC1600500 / National Key Research and Development Program of China 81703214 / National Natural Science Foundation of China
Language: English
Date published: 10/02/2018
Academic Unit: Epidemiology; Fraternal Order of Eagles Diabetes Research Center
Record Identifier: 9983995046302771

Metrics

27 Record Views

39 Times Cited - Web of Science