Journal article
Effects of a Multimodal Lifestyle Intervention on Cardiometabolic Markers in People with Progressive Multiple Sclerosis: A Secondary Analysis of a Pilot Study
Nutrients, Vol.17(7), 1163
03/27/2025
DOI: 10.3390/nu17071163
PMCID: PMC11990591
PMID: 40218921
Abstract
Background: Cardiometabolic comorbidities are common in multiple sclerosis (MS), and lifestyle interventions are effective in managing these conditions in the general population, though evidence in the MS patient population is limited. Objective: To evaluate the effect of a multimodal lifestyle intervention on serum apolipoproteins (Apo), creatine kinase (CK), glucose, and insulin in people with progressive MS (PwPMS). Methods: This study included n = 19 PwPMS who participated in a 12-month multimodal lifestyle intervention (including a modified Paleolithic diet, exercise, neuromuscular electrical stimulation, supplements, and stress reduction). Lipid profile (ApoA1, B, and E), CK, glucose, and insulin were obtained at baseline and after 12 months under fasting conditions. Results: At 12 months, there was a marginally significant decrease in ApoB (mean change: −7.17 mg/dL; 95% CI: −14.4, 0.12; p = 0.06), while no significant changes were observed for ApoA1 (mean change: −1.28 mg/dL; 95% CI: 12.33, 9.76; p = 0.80), ApoE (mean change: +0.12 mg/dL; 95% CI: −0.27, 0.52; p = 0.51), CK (mean change: +13.19 U/L; 95% CI: −32.72, 59.11; p = 0.55), Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) (mean change: −0.44; 95% CI: −1.11, 0.22; p = 0.17), and HOMA-β (mean change: +45.62; 95% CI: −95.6, 186.9; p = 0.50). A positive association was observed between changes in HOMA-IR and fatigue changes at 12 months (β = 0.81, p = 0.02), suggesting that an increase in HOMA-IR was linked to increased fatigue, which was no longer significant following the exclusion of outliers (β = 0.71, p = 0.16). Conclusions: A multimodal lifestyle intervention did not negatively impact glycemic and lipid profiles. While improvements were observed in serum biomarkers, these changes were not statistically significant, highlighting the need for stronger evidence from larger, controlled studies to confirm the cardiometabolic health benefits in PwPMS.
Details
- Title: Subtitle
- Effects of a Multimodal Lifestyle Intervention on Cardiometabolic Markers in People with Progressive Multiple Sclerosis: A Secondary Analysis of a Pilot Study
- Creators
- Arturo S. Martinez - University of IowaAlyanne J. Bastian - University of IowaFarnoosh Shemirani - University of IowaTyler J. Titcomb - University of IowaBabita Bisht - University of IowaWarren G. Darling - University of IowaMurali Ramanathan - University at Buffalo, State University of New YorkMujeeb Shittu - University at Buffalo, State University of New YorkChristine M. Gill - University of IowaLinda G. Snetselaar - University of IowaTerry L. Wahls - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Nutrients, Vol.17(7), 1163
- DOI
- 10.3390/nu17071163
- PMID
- 40218921
- PMCID
- PMC11990591
- NLM abbreviation
- Nutrients
- ISSN
- 2072-6643
- eISSN
- 2072-6643
- Publisher
- MDPI
- Grant note
- Direct-MS: U54TR001356 University of Iowa Institute for Clinical and Translational SciencesNational Center for Advancing Translational SciencesDJO Inc.Iowa City Veterans Administration Healthcare System in Iowa City, IA
This research was supported by Direct-MS, with additional in-kind contributions from the University of Iowa Institute for Clinical and Translational Sciences, funded through a Clinical and Translational Science Award (CTSA, Grant: U54TR001356) from the National Center for Advancing Translational Sciences. Other in-kind support was provided by DJO Inc., Pinnaclife Inc., TZ Press LLC, and the Iowa City Veterans Administration Healthcare System in Iowa City, IA. The views expressed in this publication are those of the authors and do not necessarily reflect the official opinions of the National Institutes of Health (NIH) or the Veterans Administration. Dr. Murali Ramanathan and his team at the University at Buffalo, State University of New York, did not receive any financial support for their involvement in this research. The funding organizations had no influence over the study's design, data collection or analysis, publication decision, or manuscript preparation.
- Language
- English
- Date published
- 03/27/2025
- Academic Unit
- Neurology; Epidemiology; Fraternal Order of Eagles Diabetes Research Center; General Internal Medicine; Health, Sport, and Human Physiology ; Internal Medicine
- Record Identifier
- 9984803712702771
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