Journal article
Effects of a dietary intervention and weight change on vasomotor symptoms in the Women's Health Initiative
Menopause (New York, N.Y.), Vol.19(9), pp.980-988
09/01/2012
DOI: 10.1097/gme.0b013e31824f606e
PMCID: PMC3428489
PMID: 22781782
Abstract
Objective: The aim of this study was to determine whether a dietary intervention designed to reduce fat intake and increase intake of fruit, vegetables, and whole grains, and weight loss, reduces vasomotor symptoms (VMS; ie, hot flashes or night sweats) in postmenopausal women.
Methods: We included 17,473 postmenopausal US women, ages 50 to 79 years, at baseline who participated in the Women's Health Initiative Dietary Modification trial and were not taking menopausal hormone therapy. Logistic regression was used to evaluate associations.
Results: In multivariate-adjusted analyses, with simultaneous adjustment for the intervention and weight change, assignment to the dietary intervention versus the control arm was significantly (odds ratio [OR], 1.14; 95% CI, 1.01-1.28) related to a higher likelihood of symptom elimination among women with VMS at baseline. In addition, women with symptoms at baseline who lost 10 lb or more (OR, 1.23; 95% CI, 1.05-1.46) or lost 10% or more of their baseline body weight (OR, 1.56; 95% CI, 1.21-2.02) between baseline and year 1 were significantly more likely to eliminate VMS compared with those who maintained weight. Upon examining the joint effect of the dietary modification and weight loss, compared with women in the control arm who maintained weight, women who lost substantial weight (>= 10%) as a part of the intervention (OR, 1.89; 95% CI, 1.39-2.57) but not as part of the control arm (OR, 1.40; 95% CI, 0.92-2.13) were significantly more likely to end VMS, although these two groups did not differ significantly from each other. Large weight loss (922 lb), but not dietary changes, was related to the elimination of moderate/severe VMS.
Conclusions: Weight loss as part of a healthy dietary modification may help eliminate VMS among postmenopausal women.
Details
- Title: Subtitle
- Effects of a dietary intervention and weight change on vasomotor symptoms in the Women's Health Initiative
- Creators
- Candyce H. Kroenke - Kaiser PermanenteBette J. Caan - Kaiser PermanenteMarcia L. Stefanick - Stanford UniversityGarnet Anderson - Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USARobert Brzyski - Univ Texas San Antonio, San Antonio, TX USAKaren C. Johnson - University of Tennessee at KnoxvilleErin LeBlanc - Kaiser PermanenteCathy Lee - Univ Calif Los Angeles, Los Angeles, CA USAAndrea Z. La Croix - Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USAHannah Lui Park - Univ Calif Irvine, Dept Epidemiol, Irvine, CA USAStacy T. Sims - Stanford UniversityMara Vitolins - Wake Forest UniversityRobert Wallace - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Menopause (New York, N.Y.), Vol.19(9), pp.980-988
- DOI
- 10.1097/gme.0b013e31824f606e
- PMID
- 22781782
- PMCID
- PMC3428489
- NLM abbreviation
- Menopause
- ISSN
- 1072-3714
- eISSN
- 1530-0374
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 9
- Grant note
- HHSN268201100046C; HHSN268201100001C; HHSN268201100002C; HHSN268201100003C; HHSN268201100004C; HHSN271201100004C / National Heart, Lung, and Blood Institute, National Institutes of Health, U.S. Department of Health and Human Services; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI)
- Language
- English
- Date published
- 09/01/2012
- Academic Unit
- Epidemiology; Injury Prevention Research Center; Internal Medicine
- Record Identifier
- 9984363573502771
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