Effects of acoustic noise on the auditory nerve compound action potentials evoked by electric pulse trains

Kirill V Nourski; Paul J Abbas; Charles A Miller; Barbara K Robinson; Fuh-Cherng Jeng

doi:10.1016/j.heares.2004.10.001

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Effects of acoustic noise on the auditory nerve compound action potentials evoked by electric pulse trains

Journal article

Peer reviewed

Effects of acoustic noise on the auditory nerve compound action potentials evoked by electric pulse trains

Kirill V Nourski, Paul J Abbas, Charles A Miller, Barbara K Robinson and Fuh-Cherng Jeng

Hearing research, Vol.202(1-2), pp.141-153

04/2005

DOI: 10.1016/j.heares.2004.10.001

PMID: 15811706

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Abstract

This study investigated the effects of acoustic noise on the auditory nerve compound action potentials in response to electric pulse trains. Subjects were adult guinea pigs, implanted with a minimally invasive electrode to preserve acoustic sensitivity. Electrically evoked compound action potentials (ECAP) were recorded from the auditory nerve trunk in response to electric pulse trains both during and after the presentation of acoustic white noise. Simultaneously presented acoustic noise produced a decrease in ECAP amplitude. The effect of the acoustic masker on the electric probe was greatest at the onset of the acoustic stimulus and it was followed by a partial recovery of the ECAP amplitude. Following cessation of the acoustic noise, ECAP amplitude recovered over a period of approximately 100–200 ms. The effects of the acoustic noise were more prominent at lower electric pulse rates (interpulse intervals of 3 ms and higher). At higher pulse rates, the ECAP adaptation to the electric pulse train alone was larger and the acoustic noise, when presented, produced little additional effect. The observed effects of noise on ECAP were the greatest at high electric stimulus levels and, for a particular electric stimulus level, at high acoustic noise levels.

Cochlear implant

Guinea pig

Compound action potential

Acoustic noise

Electric–acoustic stimulation

Adaptation

Details

Title: Subtitle: Effects of acoustic noise on the auditory nerve compound action potentials evoked by electric pulse trains
Creators: Kirill V Nourski - Department of Otolaryngology – Head and Neck Surgery, University of Iowa, Iowa City, IA 52242, USA
Paul J Abbas - Department of Otolaryngology – Head and Neck Surgery, University of Iowa, Iowa City, IA 52242, USA
Charles A Miller - Department of Otolaryngology – Head and Neck Surgery, University of Iowa, Iowa City, IA 52242, USA
Barbara K Robinson - Department of Otolaryngology – Head and Neck Surgery, University of Iowa, Iowa City, IA 52242, USA
Fuh-Cherng Jeng - Department of Speech Pathology and Audiology, University of Iowa, Iowa City, IA 52242, USA
Resource Type: Journal article
Publication Details: Hearing research, Vol.202(1-2), pp.141-153
DOI: 10.1016/j.heares.2004.10.001
PMID: 15811706
NLM abbreviation: Hear Res
ISSN: 0378-5955
eISSN: 1878-5891
Publisher: Elsevier B.V
Language: English
Date published: 04/2005
Academic Unit: Communication Sciences and Disorders; Iowa Neuroscience Institute; Neurosurgery; Otolaryngology
Record Identifier: 9984040225302771

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