Effects of activation of sympathetic nerves on cerebral blood flow during hypercapnia in cats and rabbits

D. W BUSIJA; D. D HEISTAD

doi:10.1113/jphysiol.1984.sp015051

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Effects of activation of sympathetic nerves on cerebral blood flow during hypercapnia in cats and rabbits

Journal article

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Effects of activation of sympathetic nerves on cerebral blood flow during hypercapnia in cats and rabbits

D. W BUSIJA and D. D HEISTAD

The Journal of physiology, Vol.347(1), pp.35-45

1984

DOI: 10.1113/jphysiol.1984.sp015051

PMCID: PMC1199432

PMID: 6423816

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Abstract

Effects of unilateral and bilateral activation of sympathetic nerves on cerebral blood flow (c.b.f.) and cerebrovascular resistance (c.v.r.) during hypercapnia were compared in anaesthetized cats and awake rabbits. Sympathetic nerves supplying cerebral vessels were sectioned on one or both sides in anaesthetized cats and unanaesthetized rabbits. Cerebral blood flow was measured with 15 micron radioactive microspheres. In cats, c.b.f. was greater than 110 ml/min per 100 g during hypercapnia (PCO2 greater than 65 mmHg). Unilateral section of sympathetic nerves did not change c.b.f. or c.v.r. but unilateral electrical stimulation decreased c.b.f. by 12 +/- 3% and increased c.v.r. by 15 +/- 4%. Bilateral section of sympathetic nerves decreased c.v.r. by 21 +/- 7% (P less than 0.005, compared with unilateral section) and electrical stimulation increased c.v.r. by 66 +/- 16% (P less than 0.005, compared with unilateral stimulation). In awake rabbits, c.b.f. was greater than 110 ml/min per 100 g during hypercapnia (PCO2 greater than 50 mmHg). Unilateral sympathetic denervation did not change c.v.r. but bilateral denervation decreased it by 18 +/- 8% (P less than 0.08, compared with unilateral section; P less than 0.03, compared with intact nerves). Thus, reflex activation of sympathetic nerves, as well as electrical stimulation, increases c.v.r. during hypercapnia. In addition, effects of bilateral stimulation or denervation of sympathetic nerves are greater than unilateral effects.

Fundamental and applied biological sciences. Psychology

Vertebrates: nervous system and sense organs

Biological and medical sciences

Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges

Details

Title: Subtitle: Effects of activation of sympathetic nerves on cerebral blood flow during hypercapnia in cats and rabbits
Creators: D. W BUSIJA - Univ. Iowa, coll. medicine
D. D HEISTAD - Univ. Iowa, coll. medicine
Resource Type: Journal article
Publication Details: The Journal of physiology, Vol.347(1), pp.35-45
DOI: 10.1113/jphysiol.1984.sp015051
PMID: 6423816
PMCID: PMC1199432
NLM abbreviation: J Physiol
ISSN: 0022-3751
eISSN: 1469-7793
Publisher: Blackwell; Oxford
Language: English
Date published: 1984
Academic Unit: Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine
Record Identifier: 9984040576602771

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