Effects of acute stress, relaxation, and a neurogenic inflammatory stimulus on interleukin-6 in humans

Susan K Lutgendorf; Henrietta Logan; Erin Costanzo; David Lubaroff

doi:10.1016/S0889-1591(03)00090-4

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Effects of acute stress, relaxation, and a neurogenic inflammatory stimulus on interleukin-6 in humans

Journal article

Peer reviewed

Effects of acute stress, relaxation, and a neurogenic inflammatory stimulus on interleukin-6 in humans

Susan K Lutgendorf, Henrietta Logan, Erin Costanzo and David Lubaroff

Brain, behavior, and immunity, Vol.18(1), pp.55-64

2004

DOI: 10.1016/S0889-1591(03)00090-4

PMID: 14651947

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Abstract

Effects of three experimental manipulations: mental stress, relaxation, and a nociceptive inflammatory stimulus, capsaicin, on levels of interleukin-6 (IL-6) were examined. Fifty subjects were pre-trained in relaxation and then randomized to a stress (Stroop test), relaxation (tape), or control (video) manipulation. Subjects participated in an evening reactivity session including 20 min of stress, relaxation, or control followed by a capsaicin injection in the forearm. Cardiovascular variables and levels of IL-6 were measured before and after the manipulation, and at regular intervals up to 60 min post-capsaicin. Group assignment did not differentially affect change in IL-6 over time, either before or after capsaicin. Small but significant increases in IL-6 were seen at 60 min post-capsaicin. These findings suggest that an acute stress manipulation does not modulate IL-6 within this time frame. Although IL-6 did increase following a neurogenic inflammatory stimulus, it did so subsequent to the maximum flare, suggesting that flare mechanisms are independent of IL-6.

Pro-inflammatory cytokines

Relaxation

Capsaicin

Stress

Interleukin-6

Details

Title: Subtitle: Effects of acute stress, relaxation, and a neurogenic inflammatory stimulus on interleukin-6 in humans
Creators: Susan K Lutgendorf - Department of Psychology, E11 Seashore Hall, University of Iowa, Iowa City, IA 52242, USA
Henrietta Logan - Division of Public Health Dentistry, College of Dentistry, University of Florida, Gainesville, FL 32611, USA
Erin Costanzo - Department of Psychology, E11 Seashore Hall, University of Iowa, Iowa City, IA 52242, USA
David Lubaroff - Departments of Urology and Microbiology, University of Iowa, Iowa City, IA 52242, USA
Resource Type: Journal article
Publication Details: Brain, behavior, and immunity, Vol.18(1), pp.55-64
DOI: 10.1016/S0889-1591(03)00090-4
PMID: 14651947
NLM abbreviation: Brain Behav Immun
ISSN: 0889-1591
eISSN: 1090-2139
Publisher: Elsevier Inc
Language: English
Date published: 2004
Academic Unit: Preventive and Community Dentistry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Obstetrics and Gynecology; Urology
Record Identifier: 9984065774002771

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