Journal article
Effects of adrenergic stimulation on ventilation in man
The Journal of clinical investigation, Vol.51(6), pp.1469-1475
06/1972
DOI: 10.1172/JCI106943
PMID: 4336940
Abstract
The mechanism by which catecholamines affect ventilation in man is not known. Ventilatory responses to catecholamines were observed in normal subjects before and after adrenergic receptor blockade. Intravenous infusions of norepinephrine and isoproterenol caused significant increases in minute volume and decreases in end-tidal P\nCo\n2\nwhich were blocked by the administration of propranolol, a beta adrenergic receptor blocker. The hyperventilatory response to hypoxia was not altered by propranolol.\nIntravenous infusion of phenylephrine caused a small but significant decrease in minute volume which was antagonized by phentolamine, an alpha adrenergic receptor blocker. Angiotensin, a nonadrenergic pressor agent, also decreased minute volume significantly.\n100% oxygen was administered to suppress arterial chemoreceptors. Increases in minute volume and decreases in arterial P\nCo\n2\nin response to norepinephrine and isoproterenol were blocked by breathing 100% oxygen. The decrease in minute volume during phenylephrine was not altered by 100% oxygen.\nThe results indicate that: (\na\n) beta adrenergic receptors mediate the hyperventilatory response to norepinephrine and isoproterenol but not to hypoxia. (\nb\n) the pressor agents phenylephrine and angiotensin decrease ventilation, and (\nc\n) suppression of chemoreceptors blocks the ventilatory response to norepinephrine and isoproterenol but not to phenylephrine. Implications concerning the interaction of adrenergic receptors and chemoreceptors with respect to the hyperventilatory response to catecholamines are discussed.
Details
- Title: Subtitle
- Effects of adrenergic stimulation on ventilation in man
- Creators
- Donald D Heistad - Cardiovascular Division, Department of Internal Medicine, University of Iowa College of Medicine, and Veterans Administration Hospital, Iowa City 52240Robert C Wheeler - Cardiovascular Division, Department of Internal Medicine, University of Iowa College of Medicine, and Veterans Administration Hospital, Iowa City 52240Allyn L Mark - Cardiovascular Division, Department of Internal Medicine, University of Iowa College of Medicine, and Veterans Administration Hospital, Iowa City 52240Phillip G Schmid - Cardiovascular Division, Department of Internal Medicine, University of Iowa College of Medicine, and Veterans Administration Hospital, Iowa City 52240Francois M Abboud - Cardiovascular Division, Department of Internal Medicine, University of Iowa College of Medicine, and Veterans Administration Hospital, Iowa City 52240
- Resource Type
- Journal article
- Publication Details
- The Journal of clinical investigation, Vol.51(6), pp.1469-1475
- Publisher
- American Society for Clinical Investigation
- DOI
- 10.1172/JCI106943
- PMID
- 4336940
- ISSN
- 0021-9738
- eISSN
- 1558-8238
- Language
- English
- Date published
- 06/1972
- Academic Unit
- Molecular Physiology and Biophysics; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984025464602771
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