Journal article
Effects of aging, exercise, and disease on force transfer in skeletal muscle
American journal of physiology: endocrinology and metabolism, Vol.309(1), pp.E1-E10
07/01/2015
DOI: 10.1152/ajpendo.00095.2015
PMCID: PMC4490334
PMID: 25968577
Abstract
The loss of muscle strength and increased injury rate in aging skeletal muscle has previously been attributed to loss of muscle protein (cross-sectional area) and/or decreased neural activation. However, it is becoming clear that force transfer within and between fibers plays a significant role in this process as well. Force transfer involves a secondary matrix of proteins that align and transmit the force produced by the thick and thin filaments along muscle fibers and out to the extracellular matrix. These specialized networks of cytoskeletal proteins aid in passing force through the muscle and also serve to protect individual fibers from injury. This review discusses the cytoskeleton proteins that have been identified as playing a role in muscle force transmission, both longitudinally and laterally, and where possible highlights how disease, aging, and exercise influence the expression and function of these proteins.
Details
- Title: Subtitle
- Effects of aging, exercise, and disease on force transfer in skeletal muscle
- Creators
- David C Hughes - University of California, DavisMarita A Wallace - University of California, DavisKeith Baar - University of California, Davis
- Resource Type
- Journal article
- Publication Details
- American journal of physiology: endocrinology and metabolism, Vol.309(1), pp.E1-E10
- DOI
- 10.1152/ajpendo.00095.2015
- PMID
- 25968577
- PMCID
- PMC4490334
- ISSN
- 0193-1849
- eISSN
- 1522-1555
- Grant note
- R01 AG045375 / NIA NIH HHS R01 AG-045375 / NIA NIH HHS
- Language
- English
- Date published
- 07/01/2015
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984359765702771
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