Effects of aging on mineralocorticoid-induced salt appetite in rats

Robert L Thunhorst; Terry G Beltz; Alan Kim Johnson

doi:10.1152/ajpregu.00349.2013

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Effects of aging on mineralocorticoid-induced salt appetite in rats

Journal article

Open access

Peer reviewed

Effects of aging on mineralocorticoid-induced salt appetite in rats

Robert L Thunhorst, Terry G Beltz and Alan Kim Johnson

American journal of physiology. Regulatory, integrative and comparative physiology, Vol.305(12), pp.R1498-1505

12/15/2013

DOI: 10.1152/ajpregu.00349.2013

PMCID: PMC3882696

PMID: 24133100

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Abstract

This work examined the effects of age on salt appetite measured in the form of daily saline (i.e., 0.3 M NaCl) drinking in response to administration of deoxycorticosterone acetate (DOCA; 5 mg/kg body wt) using young (4 mo), "middle-aged" adult (12 mo), and old (30 mo) male Brown Norway rats. Water and sodium intakes, excretions, and balances were determined daily. The salt appetite response was age dependent with "middle-aged" rats ingesting the most saline solution followed in order by young and then old rats. While old rats drank the least saline solution, the amounts of saline ingested still were copious and comprise an unambiguous demonstration of salt appetite in old rats. Middle-aged rats had the highest saline preference ratios of the groups under baseline conditions and throughout testing consistent with an increased avidity for sodium taste. There were age differences in renal handling of water and sodium that were consistent with a renal contribution to the greater saline intakes by middle-aged rats. There was evidence of impaired renal function in old rats, but this did not account for the reduced saline intakes of the oldest rats.

Water-Electrolyte Balance - physiology

Appetite - drug effects

Rats

Behavior, Animal - physiology

Male

Sodium Chloride - administration & dosage

Mineralocorticoids - pharmacology

Rats, Inbred BN

Animals

Aging - physiology

Sodium - urine

Desoxycorticosterone Acetate - pharmacology

Behavior, Animal - drug effects

Drinking Behavior - drug effects

Salt-Tolerance - physiology

Appetite - physiology

Body Weight - physiology

Drinking Behavior - physiology

Details

Title: Subtitle: Effects of aging on mineralocorticoid-induced salt appetite in rats
Creators: Robert L Thunhorst - Departments of Psychology
Terry G Beltz
Alan Kim Johnson
Resource Type: Journal article
Publication Details: American journal of physiology. Regulatory, integrative and comparative physiology, Vol.305(12), pp.R1498-1505
DOI: 10.1152/ajpregu.00349.2013
PMID: 24133100
PMCID: PMC3882696
NLM abbreviation: Am J Physiol Regul Integr Comp Physiol
ISSN: 0363-6119
eISSN: 1522-1490
Publisher: American Physiological Society; United States
Grant note: MH-59239 / NIMH NIH HHS AG-25465 / NIA NIH HHS P01 HL014388 / NHLBI NIH HHS DK-66086 / NIDDK NIH HHS HL-57472 / NHLBI NIH HHS HL-14388 / NHLBI NIH HHS R01 AG025465 / NIA NIH HHS
Language: English
Date published: 12/15/2013
Academic Unit: Psychological and Brain Sciences; Neuroscience and Pharmacology; Health, Sport, and Human Physiology
Record Identifier: 9984002497502771

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