Journal article
Effects of aging on the adaptive immune response to respiratory virus infections
Aging health, Vol.5(6), pp.775-775
12/01/2009
DOI: 10.2217/ahe.09.69
PMCID: PMC2822389
PMID: 20174457
Abstract
Severe acute respiratory disease caused by respiratory virus infections in individuals aged 65 years and older and in high-risk adults, such as those with chronic cardiopulmonary disorders, is associated with increased hospitalization and mortality rates. Epidemiological studies have identified influenza virus and respiratory syncytial virus as the most frequent causes of virus-induced respiratory disease in elderly and high-risk adults. Studies in both humans and animal models have established fundamental defects in cell-mediated and humoral immune responses in aged individuals. However, it is not well understood how age specifically alters the immune response to respiratory pathogens. In this review, we will focus our discussion on the major causative agents of severe respiratory virus infections in elderly and high-risk adults and the age-associated defects in the immune response that probably contribute to the increased disease severity observed in these populations.
Details
- Title: Subtitle
- Effects of aging on the adaptive immune response to respiratory virus infections
- Creators
- Ross B Fulton - Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA, Tel.: +1 319 335 8433, Fax: +1 319 335 9006Steven M Varga - Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA and Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USA, Tel.: +1 319 335 7784, Fax: +1 319 335 9006
- Resource Type
- Journal article
- Publication Details
- Aging health, Vol.5(6), pp.775-775
- DOI
- 10.2217/ahe.09.69
- PMID
- 20174457
- PMCID
- PMC2822389
- NLM abbreviation
- Aging health
- ISSN
- 1745-509X
- eISSN
- 1745-5103
- Language
- English
- Date published
- 12/01/2009
- Academic Unit
- Graduate College Admin and Gen; Microbiology and Immunology; Pathology
- Record Identifier
- 9984083890502771
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